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Review
. 2022 Dec;50(6):147.
doi: 10.3892/ijmm.2022.5203. Epub 2022 Nov 11.

Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review)

Katerina Pierouli  1 , Louis Papageorgiou  1 , Thanasis Mitsis  1 , Eleni Papakonstantinou  1 , Io Diakou  1 , Stefanos Leptidis  1 , Markezina Sigala  1 , Konstantina Dragoumani  1 , Demetrios A Spandidos  2 , Flora Bacopoulou  3 , George P Chrousos  3 , George Ν Goulielmos  4 , Elias Eliopoulos  1 , Dimitrios Vlachakis  1
Affiliations
Review

Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review)

Katerina Pierouli et al. Int J Mol Med. 2022 Dec.

Abstract

The synthesis and release of glucocorticoids in living organisms are related to their response to unfavorable stressful conditions in order to maintain homeostatic functions and survive. One such hormone in humans is cortisol, which is produced by the hypothalamic‑pituitary‑adrenal cortex axis and binds with the glucocorticoid receptor (GR) following its secretion. GR controls a number of distinct gene networks. Non‑coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs), regulate the expression and function of GR, having a considerable impact on various biological processes and treatment approaches for numerous disorders. In the present review, the GR pathways and signaling as part of the stress response system are discussed. A detailed report on the role of miRNAs and lncRNAs in glucocorticoid signaling is also presented.

Keywords: GR; endogenous glucocorticoids; glucocorticoid signaling; lncRNAs; miRNAs; stress response system.

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Conflict of interest statement

DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Network of genes related to the NR3C1 gene. Association data include protein interactions (pink lines), pathways (light blue lines), co-expression (purple lines) and protein domain similarity (yellow lines). The network was constructed using the Genemania algorithm with the human network (44). NR3C1, nuclear receptor subfamily 3 group C member 1.
Figure 2
Figure 2
Circular diagram exhibiting the extended regulatory potential of microRNAs on the GRα network. A total of 120 microRNAs were predicted to target more than one transcript of the human NR3C1 network (constructed with Genemania). microRNA root thickness corresponds to the target prediction score, as generated by the miRDB algorithm. The diagram was built using R version 4.0.3 with the chorddiag (164) package. NR3C1, nuclear receptor subfamily 3 group C member 1; GR, glucocorticoid receptor.
See this image and copyright information in PMC

References

    1. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5:374–381. doi: 10.1038/nrendo.2009.106. - DOI - PubMed
    1. Tsigos C, Kyrou I, Kassi E, Chrousos GP. Stress: Endocrine Physiology and Pathophysiology. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dungan K, Grossman A, Hershman JM, Hofland J, Kaltsas G, et al., editors. Endotext. South Dartmouth, MA: 2000. MDText.com, Inc. Copyright© 20002021, MDText.com, Inc. - PubMed
    1. Charmandari E, Kino T, Souvatzoglou E, Chrousos GP. Pediatric stress: Hormonal mediators and human development. Horm Res. 2003;59:161–179. - PubMed
    1. Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stress on body function: A review. EXCLI J. 2017;16:1057–1072. - PMC - PubMed
    1. Russell G, Lightman S. The human stress response. Nat Re Endocrinol. 2019;15:525–534. doi: 10.1038/s41574-019-0228-0. - DOI - PubMed