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. 2023 Feb 16;29(10):e202203243.
doi: 10.1002/chem.202203243. Epub 2022 Dec 29.

Asymmetric Ruthenium Catalysis Enables Fluorophores with Point Chirality Displaying CPL Properties

Yang Sun  1 , Kais Dhbaibi  1 , Hortense Lauwick  1 , Claudia Lalli  1 , Gregory Taupier  1 , Yann Molard  1 , Rafael Gramage-Doria  1 , Sylvie Dérien  1 , Jeanne Crassous  1 , Mathieu Achard  1
Affiliations

Asymmetric Ruthenium Catalysis Enables Fluorophores with Point Chirality Displaying CPL Properties

Yang Sun et al. Chemistry. .

Abstract

A novel enantiopure π-allylruthenium(IV) precatalyst allowed the enantioselective and stereospecific allylations of indoles and gave access to indolin-3-ones, containing vicinal stereogenic centers. Facile separation of diastereoisomers exhibiting opposite circularly polarized luminescence (CPL) activities in diverse solvents, including water, demonstrated the potential of these sustainable transformations and of the newly prepared molecules.

Keywords: CPL; chirality; enantioselectivity; fluorescence; stereoselectivity.

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References

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