Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;50(1):889-897.
doi: 10.1007/s11033-022-08073-x. Epub 2022 Nov 11.

Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer

Xiao-Han Xu #  1 , Shu-Li Shao #  2 , Dong Guo  2 , Li-Na Ge  3 , Zan Wang  1 , Peng Liu  2 , Yuan-Yong Tao  4
Affiliations

Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer

Xiao-Han Xu et al. Mol Biol Rep. 2023 Jan.

Abstract

Helicobacter pylori (H. pylori) is a common pathogen that infects more than half of the world's population. Its infection can not only lead to a variety of gastrointestinal diseases, such as chronic gastritis and gastric cancer (GC) but also be associated with many extra-gastrointestinal diseases. Exosomes, as a new intercellular information transmission medium, can carry biological signal molecules such as microRNAs (miRNAs) to regulate a variety of cellular physiological activities and are involved in multiple cancer processes. In this article, we provide a systematic review on the role of exosomal miRNAs in H. pylori-associated GC.

Keywords: Exosomal miRNAs; Exosomes; Gastric cancer; Helicobacter pylori.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. FitzGerald R, Smith SM (2021) An overview of helicobacter pylori infection[J]. Methods Mol Biol 2283:1–14 - PubMed - DOI
    1. Liu X, Ma R, Yi B et al (2021) MicroRNAs are involved in the development and progression of gastric cancer[J]. Acta Pharmacol Sin 42(7):1018–1026 - PubMed - DOI
    1. Ingenito F, Roscigno G, Affinito A et al (2019) The role of Exo-miRNAs in cancer: a focus on therapeutic and diagnostic applications[J]. Int J Mol Sci 20(19):4687 - PubMed - PMC - DOI
    1. Tegtmeyer N, Neddermann M, Asche CI et al (2017) Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA[J]. Mol Microbiol 105(3):358–372 - PubMed - DOI
    1. Selbach M, Schwanhäusser B, Thierfelder N et al (2008) Widespread changes in protein synthesis induced by microRNAs[J]. Nature 455(7209):58–63 - PubMed - DOI

Publication types

LinkOut - more resources