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. 2023 Jan;50(1):889-897.
doi: 10.1007/s11033-022-08073-x. Epub 2022 Nov 11.

Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer

Xiao-Han Xu #  1 , Shu-Li Shao #  2 , Dong Guo  2 , Li-Na Ge  3 , Zan Wang  1 , Peng Liu  2 , Yuan-Yong Tao  4
Affiliations

Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer

Xiao-Han Xu et al. Mol Biol Rep. 2023 Jan.

Abstract

Helicobacter pylori (H. pylori) is a common pathogen that infects more than half of the world's population. Its infection can not only lead to a variety of gastrointestinal diseases, such as chronic gastritis and gastric cancer (GC) but also be associated with many extra-gastrointestinal diseases. Exosomes, as a new intercellular information transmission medium, can carry biological signal molecules such as microRNAs (miRNAs) to regulate a variety of cellular physiological activities and are involved in multiple cancer processes. In this article, we provide a systematic review on the role of exosomal miRNAs in H. pylori-associated GC.

Keywords: Exosomal miRNAs; Exosomes; Gastric cancer; Helicobacter pylori.

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