Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;50(1):937-941.
doi: 10.1007/s11033-022-08080-y. Epub 2022 Nov 11.

lncRNAs dysregulation in monocytes from primary antiphospholipid syndrome patients: a bioinformatic and an experimental proof-of-concept approach

Carlos A Guzmán-Martín #  1   2 , Yaneli Juárez-Vicuña #  2 , Aarón Domínguez-López  1 , Javier González-Ramírez  3 , Luis M Amezcua-Guerra  2   4 , Laura A Martínez-Martínez  5 , Fausto Sánchez-Muñoz  6
Affiliations

lncRNAs dysregulation in monocytes from primary antiphospholipid syndrome patients: a bioinformatic and an experimental proof-of-concept approach

Carlos A Guzmán-Martín et al. Mol Biol Rep. 2023 Jan.

Abstract

Background: Antiphospholipid syndrome (APS) is the main cause of acquired thrombophilia where peripheral circulating cells such as monocytes have a key role. Currently, several studies have linked long non-coding RNAs (lncRNAs) in different inflammatory and autoimmune processes, including lupus. However, the role of lncRNAs in antiphospholipid syndrome is unknown, therefore, we aimed to select and measure expression levels of three lncRNAs based on its abundance in monocytes from APS patients.

Methods: Selection of lncRNAs candidates were carried out based on its abundance in monocytes and their relationship with Perez-Sanchez miRNA signature by using miRNet 2.0 bioinformatic tool, then lncRNAs expression levels was measured in monocytes by RT-qPCR.

Results: This is the first study to report that lncRNAs: FGD5-AS1, OIP5-AS1 and GAS5 are promising candidates for play a role on APS monocytes and they are expressed differently between patients and controls.

Conclusions: OIP5-AS1, FGD5-AS1 and GAS5 are downregulated on monocytes from APS patients.

Keywords: Antiphospholipid syndrome; FGD5-AS1; GAS5; Long noncoding RNAs; Monocytes; OIP5-AS1.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sayar Z, Moll R, Isenberg D, Cohen H (2020) Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management. Thrombosis Res 198:213–221 - DOI
    1. Miyakis S et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306 - DOI
    1. Juárez-Vicuña Y et al (2021) miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome. Rheumatol Int 41(7):1329–1335 - DOI
    1. Pérez-Sánchez L et al (2021) Characterization of antiphospholipid syndrome atherothrombotic risk by unsupervised integrated transcriptomic analyses. Arterioscler Thromb Vasc Biol 41:865–877 - DOI
    1. Wu GC et al (2015) Emerging role of long noncoding RNAs in autoimmune diseases. Autoimmun Rev 14:798–805 - DOI

LinkOut - more resources