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. 2023 Feb;72(1):25-30.
doi: 10.1016/j.ancard.2022.10.006. Epub 2022 Oct 26.

[Influence of arterial hypertension on the clinical profile and prognosis of patients hospitalized for COVID-19 in the city of Bukavu, in the Democratic Republic of Congo : Prospective cohort study]

[Article in French]
Chibinda Birato Yannick  1 , Muderhwa Busingo Justin  1 , Nabintu Barinjibanjwa Aimerance  1 , Bijira Bertin  1 , Kingombe Muzaliya  1 , Murhula Katabana Delphin  1 , Katchunga Bianga Philippe  2
Affiliations

[Influence of arterial hypertension on the clinical profile and prognosis of patients hospitalized for COVID-19 in the city of Bukavu, in the Democratic Republic of Congo : Prospective cohort study]

[Article in French]
Chibinda Birato Yannick et al. Ann Cardiol Angeiol (Paris). 2023 Feb.

Abstract
in English, French

Problem: There are no studies on the association between high blood pressure and COVID-19 in South Kivu.

Objective: to determine the influence of arterial hypertension on the clinical characteristics and prognosis of COVID-19 patients hospitalized in the city of Bukavu.

Methodology: Between June 2020 and June 2022, an open cohort of hypertensive and non-hypertensive COVID-19 patients admitted to two clinics in the city of Bukavu was formed. The primary endpoint was the occurrence of death. Thus, a prospective modeling of mortality by the Kaplan-Meier estimator was carried out.

Results: Among the 178 admissions for COVID-19, 68 (38.2%) patients were hypertensive. Compared to non-hypertensives, hypertensive patients were significantly older [61.0 (56.0-71.0) vs. 48.0 (32.7-64.0); p < 0,0001). During the observation period of 1059 patient-days, the incidence of death (3.2/100 patient-days) was non-significantly higher in hypertensive patients (4.3/100 patient-days) (p = 0.06). On the other hand, the independent predictors of death were Sepsis [adjusted HR = 3.7 (1.5-8.7)], CRP > 100 mg/L [adjusted HR = 3.0 (1.2-7, 0)] and SaO2 < 90 % [adjusted HR = 3.9 (1.3-11.8)].

Conclusion: This study shows that hypertension was very common in patients admitted for COVID-19 in the city of Bukavu but did not influence the vital prognosis of the latter, thus confirming the finds of most authors who have addressed the question.

Problématique: Aucune étude ne s'est penchée sur l'association entre l'hypertension artérielle et la COVID-19 au Sud-Kivu.

Objectif: Le présent travail voudrait déterminer l'influence de l'hypertension artérielle sur les caractéristiques cliniques et le pronostic des patients COVID-19 hospitalisés dans la ville de Bukavu.

Méthodologie: Entre juin 2020 et juin 2022, une cohorte ouverte des patients COVID-19 hypertendus et non hypertendus admis en hospitalisation dans deux cliniques de la ville de Bukavu a été constituée. Le critère de jugement primaire était la survenue du décès. Ainsi, une modélisation prospective de la mortalité par l'estimateur KaplanMeier a été réalisée.

Résultats: Parmi les 178 admissions pour COVID-19, 68 (38,2 %) patients étaient hypertendus. Comparés aux non hypertendus, les patients hypertendus étaient significativement plus âgés [61,0 (56,0–71,0) vs 48,0 (32,7–64,0) ; p < 0,0001). Au cours de la période d'observation de 1059 patient-jour, l'incidence du décès (3,2/100 patient-jour) était non significativement plus élevée chez les patients hypertendus (4,3/100 patient-jour) (p = 0,06). En revanche, les prédicteurs indépendants du décès étaient le Sepsis [HR ajusté = 3,7 (1,5–8,7)], une CRP > 100 mg/L [HR ajusté = 3,0 (1,2–7,0)] et une SaO2 < 90 % [HR ajusté = 3,9 (1,3–11,8)].

Conclusion: La présente étude montre que l'HTA était très fréquente chez les patients admis pour COVID-19 dans la ville de Bukavu mais n'influençait pas le pronostic vital de ces derniers confirmant ainsi les conclusions de la majorité des auteurs ayant abordé la question.

Keywords: Arterial hypertension; Bukavu; COVID-19; Clinical profile; Profil clinique; Prognosis; hypertension artérielle; pronostic.

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