Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;28(1):51-59.
doi: 10.1111/nep.14131. Epub 2022 Nov 21.

Pre-transplant serum Beta Trace Protein indicates risk for post-transplant major cardiac adverse events

Sebastian Schwab  1   2 , Daniel Pörner  1 , Carola-Ellen Kleine  1 , Roxana Werberich  1 , Louisa Werberich  1 , Stephan Reinhard  1 , Dominik Bös  3 , Christian P Strassburg  1 , Sibylle von Vietinghoff  1 , Philipp Lutz  1 , Rainer P Woitas  4
Affiliations

Pre-transplant serum Beta Trace Protein indicates risk for post-transplant major cardiac adverse events

Sebastian Schwab et al. Nephrology (Carlton). 2023 Jan.

Abstract

Background: Beta Trace Protein (BTP) is a biomarker for residual kidney function which has been linked to cardiovascular and all-cause mortality in haemodialysis patients. Following renal transplantation, recipients remain at increased risk for cardiovascular events compared with the general population. We aimed to determine the relationship of pre-transplant BTP to major adverse cardiac events (MACE) in patients following kidney transplantation.

Methods: We included 384 patients with end-stage renal disease who received a kidney transplant. MACE was defined as myocardial infarction (ST-segment elevation or non-ST-segment elevation, stroke or transient ischemic attack), coronary artery disease requiring intervention or bypass or death for cardiovascular reason. The association between pre-transplant serum BTP concentration and post-transplant MACE was evaluated by Kaplan-Meier and Cox regression analyses.

Results: Post-transplant MACE occurred in 70/384 patients. Pre-transplant BTP was significantly higher in patients with post-transplant MACE (14.36 ± 5.73 mg/l vs. 11.26 ± 5.11 mg/l; p < .01). Next to smoking (HR 1.81), age > 56.38 years (HR 1.97) and pre-existing coronary heart disease (HR 8.23), BTP above the cut off value of 12.7 mg/l was confirmed as independent risk factor for MACE (HR 2.02, all p < .05). MACE-free survival inversely correlated with pre-transplant BTP levels.

Conclusions: Pre-transplant serum BTP concentration may identify renal transplant recipients with higher risk of post-transplant MACE.

Keywords: Beta Trace Protein; major cardiovascular event; renal transplantation.

PubMed Disclaimer

References

REFERENCES

    1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296-1305. doi:10.1056/NEJMoa041031
    1. Neale J. Cardiovascular risk factors following renal transplant. World J Transplant. 2015;5(4):183. doi:10.5500/wjt.v5.i4.183
    1. Sarnak MJ, Amann K, Bangalore S, et al. Chronic kidney disease and coronary artery disease. J Am Coll Cardiol. 2019;74(14):1823-1838. doi:10.1016/j.jacc.2019.08.1017
    1. Valdivielso JM, Rodríguez-Puyol D, Pascual J, et al. Atherosclerosis in chronic kidney disease. Arterioscler Thromb Vasc Biol. 2019;39(10):1938-1966. doi:10.1161/atvbaha.119.312705
    1. Wanner C, Amann K, Shoji T. The heart and vascular system in dialysis. Lancet. 2016;388(10041):276-284. doi:10.1016/s0140-6736(16)30508-6

Substances

LinkOut - more resources