Reproducibility of T_1ρ and T₂ quantification in a multi-vendor multi-site study

R Lartey¹, A Nanavati¹, J Kim¹, M Li¹, K Xu¹, K Nakamura¹, W Shin², C S Winalski³, N Obuchowski⁴, E Bahroos⁵, T M Link⁵, P A Hardy⁶, Q Peng⁷, J Kim⁸, K Liu⁹, M Fung¹⁰, C Wu¹¹, X Li¹²

Affiliations

¹ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.
² Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA.
³ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA.
⁴ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH, USA.
⁵ Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA.
⁶ Department of Radiology, University of Kentucky, Lexington KY, USA.
⁷ Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
⁸ Arthritis Foundation, GA, USA.
⁹ Siemens Medical Solution Inc., USA.
¹⁰ GE Healthcare, Waukesha, WI, USA.
¹¹ Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹² Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: lix6@ccf.org.

PMID: 36370959
PMCID: PMC10016129
DOI: 10.1016/j.joca.2022.10.017

Reproducibility of T_1ρ and T₂ quantification in a multi-vendor multi-site study

R Lartey et al. Osteoarthritis Cartilage. 2023 Feb.

. 2023 Feb;31(2):249-257.

doi: 10.1016/j.joca.2022.10.017. Epub 2022 Nov 10.

Authors

Affiliations

¹ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.
² Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA.
³ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA.
⁴ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH, USA.
⁵ Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA.
⁶ Department of Radiology, University of Kentucky, Lexington KY, USA.
⁷ Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
⁸ Arthritis Foundation, GA, USA.
⁹ Siemens Medical Solution Inc., USA.
¹⁰ GE Healthcare, Waukesha, WI, USA.
¹¹ Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹² Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: lix6@ccf.org.

PMID: 36370959
PMCID: PMC10016129
DOI: 10.1016/j.joca.2022.10.017

Abstract

Objective: To evaluate the multi-vendor multi-site reproducibility of two-dimensional (2D) multi-echo spin-echo (MESE) T₂ mapping (product sequences); and to evaluate the longitudinal reproducibility of three-dimensional (3D) magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (MAPSS) T_1ρ and T₂ mapping (research sequences), and 2D MESE T₂ mapping, separated by 6 months, in a multi-vendor multi-site setting.

Methods: Phantoms and volunteers (n = 5 from each site, n = 20 in total) were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens, General Electric, and Phillips). Two traveling volunteers (3 knees) scanned at all 4 sites at baseline and 6-month follow-up. Data was transferred to one site for centralized processing. Coefficients of variation (CVs) were calculated to evaluate reproducibility.

Results: For baseline 2D MESE T₂ measures, average CV were 0.37-2.45% (intra-site) and 5.96% (inter-site) for phantoms, and 3.15-8.49% (intra-site) and 14.16% (inter-site) for volunteers. For longitudinal phantom data, intra-site CVs were 1.42-3.48% for 3D MAPSS T_1ρ, 1.77-3.56% for 3D MAPSS T₂, and 1.02-2.54% for 2D MESE T₂. For the longitudinal volunteer data, the intra-site CVs were 2.60-4.86% for 3D MAPSS T_1ρ, 3.33-7.25% for 3D MAPSS T₂, and 3.11-8.77% for 2D MESE T₂.

Conclusion: This study demonstrated excellent intra-site reproducibility of 2D MESE T₂ imaging, while its inter-site variation was slightly higher than 3D MAPSS T₂ imaging (10.06% as previously reported). This study also showed excellent reproducibility of longitudinal T_1ρ and T₂ cartilage quantification, in a multi-vendor multi-site setting for both product 2D MESE T₂ and 3D MAPSS T_1p/T₂ research sequences.

Keywords: Cartilage imaging; Magnetic resonance imaging; Repeatability; Reproducibility; T(1ρ); T(2).

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References

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Reproducibility of T_1ρ and T₂ quantification in a multi-vendor multi-site study

Affiliations

Reproducibility of T_1ρ and T₂ quantification in a multi-vendor multi-site study

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

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Full Text Sources

Medical