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Review
. 2023 Jan;95(1):e28306.
doi: 10.1002/jmv.28306.

Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies

Ali A Rabaan  1   2   3 , Abdul Hawil Abas  4 , Trina Ekawati Tallei  5 , Mona A Al-Zaher  6 , Noor M Al-Sheef  6 , Fatimawali  7 , Esraa Z Al-Nass  6 , Eba A Al-Ebrahim  6 , Yunus Effendi  8 , Rinaldi Idroes  9 , Mather F Alhabib  10 , Hussain A Al-Fheid  10 , Ahmad Akroman Adam  11 , Talha Bin Emran  12   13
Affiliations
Review

Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies

Ali A Rabaan et al. J Med Virol. 2023 Jan.

Abstract

Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The disease can result in flu-like symptoms, fever, and a persistent rash. The disease is currently spreading throughout the world and prevention and treatment efforts are being intensified. Although there is no treatment that has been specifically approved for monkeypox virus infection, infected patients may benefit from using certain antiviral medications that are typically prescribed for the treatment of smallpox. The drugs are tecovirimat, brincidofovir, and cidofovir, all of which are currently in short supply due to the spread of the monkeypox virus. Resistance is also a concern, as widespread replication of the monkeypox virus can lead to mutations that produce monkeypox viruses that are resistant to the currently available treatments. This article discusses monkeypox disease, potential drug targets, and management strategies to overcome monkeypox disease. With the discovery of new drugs, it is hoped that the problem of insufficient drugs will be resolved, and it is not anticipated that drug resistance will become a major issue in the near future.

Keywords: Monkeypox; disease management; drug target; orthopoxvirus.

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References

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