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Comment
. 2023 Jan;38(1):21-22.
doi: 10.1002/mds.29272. Epub 2022 Nov 14.

Identification of Novel α-Synuclein Assemblies in Lewy Body Disease

Arpine Sokratian #  1 , Hjalte Gram #  2 , Poul H Jensen  2 , Andrew B West  1
Affiliations
Comment

Identification of Novel α-Synuclein Assemblies in Lewy Body Disease

Arpine Sokratian et al. Mov Disord. 2023 Jan.
No abstract available

Keywords: CryoEM; Parkinson's disease; SNCA.

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Conflict of interest statement

Relevant Conflicts of interests/Financial disclosures

The authors declare no relevant conflicts of interest of financial disclosures related to this manuscript.

Comment on

  • Structures of α-synuclein filaments from human brains with Lewy pathology.
    Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M. Yang Y, et al. Nature. 2022 Oct;610(7933):791-795. doi: 10.1038/s41586-022-05319-3. Epub 2022 Sep 15. Nature. 2022. PMID: 36108674 Free PMC article.

References

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    1. Yang Y, Shi Y, Schweighauser M, et al. Structures of α-synuclein filaments from human brains with Lewy pathology. Nature 2022. - PMC - PubMed
    1. Van der Perren A, Gelders G, Fenyi A, et al. The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol 2020;139(6):977–1000. - PMC - PubMed
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    1. Candelise N, Schmitz M, Llorens F, et al. Seeding variability of different alpha synuclein strains in synucleinopathies. Ann Neurol 2019;85(5):691–703. - PubMed

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