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. 2022 Dec:130:42-45.
doi: 10.1016/j.placenta.2022.11.002. Epub 2022 Nov 7.

Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

Juliana Ferreira Floriano  1 , Angélica Mércia Pascon Barbosa  2 , Rafael Guilen de Oliveira  3 , Sofía Vega  4 , Bruna Bologna Catinelli  5 , Gabriela Azevedo Garcia  3 , David Rafael Reyes  3 , Luis Sobrevia  6 , Marilza Vieira Cunha Rudge  7 ; DIAMATER Study Group
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Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

Juliana Ferreira Floriano et al. Placenta. 2022 Dec.

Abstract

Induction of diabetes mellitus by streptozotocin (STZ) in rats at birth is of high mortality and low success rate when male puppies are separated from females, prioritizing females breastfeeding. Cross-parental care of the entire litter and SZT-induced diabetes up to 12 h post-birth become with high success rate, low animal death, and females with glycaemia >140 mg/dL on the 90 postnatal day. Cross-parental care is more effective in STZ-induction of diabetes, which is maintained during pregnancy (diabetes in pregnancy), than the conventional protocol of male separation at birth.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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