High-fidelity fluid structure interaction simulations of turbulent-like aneurysm flows reveals high-frequency narrowband wall vibrations: A stimulus of mechanobiological relevance?

Abstract

Recent high-fidelity/resolution computational fluid dynamics simulations of intracranial aneurysm hemodynamics have revealed turbulent-like flows. We hypothesized that the associated high-frequency pressure fluctuations could promote aneurysm wall vibrations. We performed fully coupled high-fidelity transient fluid structure interaction simulations between the blood flow and compliant aneurysm sac wall taking 5,000 time steps per second using a 3D patient-specific model previously shown to harbour turbulent-like flow. Our results show that the flow velocity contained fluctuations with a smooth and continuously decaying energy up to ∼160Hz, and fluctuating pressures with characteristic frequency peaks at approximately 30, 130 and 210Hz. There was a strong two-way coupling between the pressure and the wall deformation, for which the frequency spectrum showed similar characteristics, but with a narrow band peak at ∼120Hz with large regional differences in amplitude up to 80μm. The physics of the flow is broadly consistent with clinical reports of turbulent-like flows, while the physics of the wall is consistent with reports of spectral peaks in aneurysm patients. As many aneurysms are known to harbour turbulent-like flows, wall vibrations could be a widespread phenomenon. Finally, since aneurysms are vascular pathologies by definition and many/most aneurysms do not have endothelial cells but still display a focal remodeling, we hypothesize that vibrations and stresses within the wall itself might play a role in the mechanobiological processes of vessel wall pathology.

Keywords: Aneurysm wall vibration; Cerebral aneurysm; Flow instabilities; Fluid structure interaction.