Multicenter Study
doi: 10.1016/j.arbres.2022.09.005.
Epub 2022 Sep 22.
Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia
[Article in
English,
Spanish]
Sergi Pascual-Guardia
1
, Francesco Amati
2
, Judith Marin-Corral
3
, Stefano Aliberti
4
, Joaquim Gea
5
, Nilam J Soni
6
, Alejandro Rodriguez
7
, Oriol Sibila
8
, Francisco Sanz
9
, Giovanni Sotgiu
10
, Pedro J Marcos
11
, Ane Uranga
12
, Branislava Milenkovic
13
, Christian N Meyer
14
, Martin Kolditz
15
, Antonio R Anzueto
6
, Marcos I Restrepo
16
; GLIMP investigators
Collaborators,
Affiliations
Collaborators
-
GLIMP investigators:
Patricia Karina Aruj 17 , Silvia Attorri 17 , Enrique Barimboim 17 , Juan Pablo Caeiro 17 , María I Garzón 17 , Victor Hugo Cambursano 17 , Adrian Ceccato 17 , Julio Chertcoff 17 , Florencia Lascar 17 , Fernando Di Tulio 17 , Ariel Cordon Díaz 17 , Lautaro de Vedia 17 , Maria Cristina Ganaha 17 , Sandra Lambert 17 , Gustavo Lopardo 17 , Carlos M Luna 17 , Alessio Gerardo Malberti 17 , Nora Morcillo 17 , Silvina Tartara 17 , Claudia Pensotti 17 , Betiana Pereyra 17 , Pablo Gustavo Scapellato 17 , Juan Pablo Stagnaro 17 , Sonali Shah 18 , Felix Lötsch 19 , Florian Thalhammer 19 , Kurt Anseeuw 20 , Camille A Francois 20 , Eva Van Braeckel 20 , Jean Louis Vincent 20 , Marcel Zannou Djimon 21 , Jules Bashi 21 , Roger Dodo 21 , Simone Aranha Nouér 22 , Peter Chipev 23 , Milena Encheva 23 , Darina Miteva 23 , Diana Petkova 23 , Adamou Dodo Balkissou 24 , Eric Walter Pefura Yone 24 , Bertrand Hugo Mbatchou Ngahane 24 , Ning Shen 25 , Jin-Fu Xu 25 , Carlos Andres Bustamante Rico 26 , Ricardo Buitrago 26 , Fernando Jose Pereira Paternina 26 , Jean-Marie Kayembe Ntumba 27 , Vesna Vladic Carevic 28 , Marko Jakopovic 28 , Mateja Jankovic 28 , Zinka Matkovic 28 , Ivan Mitrecic 28 , Marie-Laure Bouchy Jacobsson 29 , Anette Bro Christensen 29 , Uffe Bødtger 29 , Christian Niels Meyer 29 , Andreas Vestergaard Jensen 29 , Gertrud Baunbæk-Knudsen 29 , Pelle Trier Petersen 29 , Stine Andersen 29 , Ibrahim El-Said Abd El-Wahhab 30 , Nesreen Elsayed Morsy 30 , Hanaa Shafiek 30 , Eman Sobh 30 , Kedir Abdella Abdulsemed 31 , Fabrice Bertrand 32 , Christian Brun-Buisson 32 , Etienne de Montmollin 32 , Muriel Fartoukh 32 , Jonathan Messika 32 , Pierre Tattevin 32 , Abdo Khoury 32 , Bernard Ebruke 33 , Michael Dreher 34 , Martin Kolditz 34 , Matthias Meisinger 34 , Mathias W Pletz 34 , Stefan Hagel 34 , Jan Rupp 34 , Tom Schaberg 34 , Marc Spielmanns 34 , Petra Creutz 34 , Norton Suttorp 34 , Beatrice Siaw-Lartey 35 , Katerina Dimakou 36 , Mina Gaga 36 , Dimosthenis Papapetrou 36 , Evdoxia Tsigou 36 , Dimitrios Ampazis 36 , Evangelos Kaimakamis 36 , Mohit Bhatia 37 , Raja Dhar 37 , George D'Souza 37 , Rajiv Garg 37 , Parvaiz A Koul 37 , P A Mahesh 37 , B S Jayaraj 37 , Kiran Vishnu Narayan 37 , Hirennappa B Udnur 37 , Shashi Bhaskara Krishnamurthy 37 , Surya Kant 37 , Rajesh Swarnakar 37 , Sneha Limaye 37 , Sundeep Salvi 37 , Keihan Golshani 38 , Vera M Keatings 39 , Ignacio Martin-Loeches 39 , Yasmin Maor 40 , Jacob Strahilevitz 40 , Salvatore Battaglia 41 , Maria Carrabba 41 , Piero Ceriana 41 , Marco Confalonieri 41 , Antonella d'Arminio Monforte 41 , Bruno Del Prato 41 , Marino De Rosa 41 , Riccardo Fantini 41 , Paola Faverio 41 , Giuseppe Fiorentino 41 , Maria Antonia Gammino 41 , Francesco Menzella 41 , Giuseppe Milani 41 , Stefano Nava 41 , Gerardo Palmiero 41 , Roberta Petrino 41 , Barbara Gabrielli 41 , Paolo Rossi 41 , Claudio Sorino 41 , Gundi Steinhilber 41 , Alessandro Zanforlin 41 , Fabio Franzetti 41 , Manuela Carugati 41 , Manuela Morosi 41 , Elisa Monge 41 , Mauro Carone 41 , Vincenzo Patella 41 , Simone Scarlata 41 , Andrea Comel 41 , Kiyoyasu Kurahashi 42 , Zeina Aoun Bacha 43 , Daniel Barajas Ugalde 44 , Omar Ceballos Zuñiga 44 , José F Villegas 44 , Milic Medenica 45 , E M W van de Garde 46 , Deebya Raj Mihsra 47 , Poojan Shrestha 47 , Elliott Ridgeon 48 , Babatunde Ishola Awokola 49 , Ogonna N O Nwankwo 49 , Adefuye Bolanle Olufunlola 49 , Segaolu Olumide 49 , Kingsley N Ukwaja 49 , Muhammad Irfan 50 , Lukasz Minarowski 51 , Skoczyński Szymon 51 , Felipe Froes 52 , Pedro Leuschner 52 , Mariana Meireles 52 , Cláudia Ferrão 52 , João Neves 52 , Sofia B Ravara 52 , Victoria Brocovschii 53 , Chesov Ion 53 , Doina Rusu 53 , Cristina Toma 53 , Daniela Chirita 54 , Carmen Mihaela Dorobat 54 , Alexei Birkun 55 , Anna Kaluzhenina 55 , Abdullah Almotairi 56 , Zakeya Abdulbaqi Ali Bukhary 56 , Jameela Edathodu 56 , Amal Fathy 56 , Abdullah Mushira Abdulaziz Enani 56 , Nazik Eltayeb Mohamed 56 , Jawed Ulhadi Memon 56 , Abdelhaleem Bella 56 , Nada Bogdanović 57 , Branislava Milenkovic 57 , Dragica Pesut 57 , Luis Borderìas 58 , Noel Manuel Bordon Garcia 58 , Hugo Cabello Alarcón 58 , Catia Cilloniz 58 , Antoni Torres 58 , Vicens Diaz-Brito 58 , Xavier Casas 58 , Alicia Encabo González 58 , Maria Luisa Fernández-Almira 58 , Miguel Gallego 58 , Inmaculada Gaspar-García 58 , Juan González Del Castillo 58 , Patricia Javaloyes Victoria 58 , Elena Laserna Martínez 58 , Rosa Malo de Molina 58 , Pedro J Marcos 58 , Rosario Menéndez 58 , Ana Pando-Sandoval 58 , Cristina Prat Aymerich 58 , Alicia Lacoma de la Torre 58 , Ignasi García-Olivé 58 , Jordi Rello 58 , Silvia Moyano 58 , Francisco Sanz 58 , Oriol Sibila 58 , Ana Rodrigo-Troyano 58 , Jordi Solé-Violán 58 , Ane Uranga 58 , Job F M van Boven 58 , Ester Vendrell Torra 58 , Jordi Almirall Pujol 58 , Charles Feldman 59 , Ho Kee Yum 60 , Arnauld Attannon Fiogbe 61 , Ferdaous Yangui 62 , Semra Bilaceroglu 63 , Levent Dalar 63 , Ufuk Yilmaz 63 , Artemii Bogomolov 64 , Naheed Elahi 65 , Devesh J Dhasmana 66 , Andrew Feneley 66 , Rhiannon Ions 66 , Julie Skeemer 66 , Gerrit Woltmann 66 , Carole Hancock 66 , Adam T Hill 66 , Banu Rudran 66 , Silvia Ruiz-Buitrago 66 , Marion Campbell 66 , Paul Whitaker 66 , Alexander Youzguin 66 , Anika Singanayagam 66 , Karen S Allen 67 , Veronica Brito 67 , Jessica Dietz 67 , Claire E Dysart 67 , Susan M Kellie 67 , Ricardo A Franco-Sadud 67 , Garnet Meier 67 , Thomas L Holland 67 , Stephen P Bergin 67 , Fayez Kheir 67 , Mark Landmeier 67 , Manuel Lois 67 , Girish B Nair 67 , Hemali Patel 67 , Katherine Reyes 67 , William Rodriguez-Cintron 67 , Shigeki Saito 67 , Nilam J Soni 67 , Julio Noda 67 , Cecilia I Hinojosa 67 , Stephanie M Levine 67 , Luis F Angel 67 , Luis F Reyes 67 , Antonio Anzueto 67 , K Scott Whitlow 67 , John Hipskind 67 , Kunal Sukhija 67 , Vicken Totten 67 , Richard G Wunderink 67 , Ray D Shah 67 , Kondwelani John Mateyo 68 , Lorena Noriega, Ezequiel Alvarado, Mohamed Aman, Lucía Labra
Affiliations
- 1 Respiratory Department, Hospital del Mar-IMIM, CEXS, UPF, CIBERES, BRN, Barcelona, Spain; Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA.
- 2 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy.
- 3 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Critical Care Department, Hospital del Mar-IMIM, Critical Illness Research Group (GREPAC), Barcelona,Spain.
- 4 Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy.
- 5 Respiratory Department, Hospital del Mar-IMIM, CEXS, UPF, CIBERES, BRN, Barcelona, Spain.
- 6 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Section of Pulmonary & Critical Care Medicine, South Texas Veterans Health Care System,USA.
- 7 Critical Care Department, Hospital Universitari Joan XXIII, URV, CIBERES, Tarragona, Spain.
- 8 Respiratory Department, Hospital Clinic, CIBERES, BRN, Barcelona, Spain.
- 9 Pulmonology Department, Consorci Hospital General Universitari de Valencia, Valencia,Spain.
- 10 Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari,Italy.
- 11 Servicio de Neumología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC) Sergas Universidade da Coruña (UDC),A Coruña,Spain.
- 12 Pulmonology Department, Hospital of Galdakao-Usansolo,Spain.
- 13 Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade,Serbia.
- 14 Department of Internal Medicine, Roskilde Hospital, Copenhagen University Hospital, Roskilde,Denmark.
- 15 Division of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus, Technische Universität Dresden,Germany.
- 16 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Section of Pulmonary & Critical Care Medicine, South Texas Veterans Health Care System,USA. Electronic address: restrepom@uthscsa.edu.
- 17 Argentina.
- 18 Australia.
- 19 Austria.
- 20 Belgium.
- 21 Benin.
- 22 Brazil.
- 23 Bulgaria.
- 24 Cameroon.
- 25 China.
- 26 Colombia.
- 27 Congo.
- 28 Croatia.
- 29 Denmark.
- 30 Egypt.
- 31 Ethiopia.
- 32 France.
- 33 Gambia.
- 34 Germany.
- 35 Ghana.
- 36 Greece.
- 37 India.
- 38 Iran.
- 39 Ireland.
- 40 Israel.
- 41 Italy.
- 42 Japan.
- 43 Lebanon.
- 44 Mexico.
- 45 Montenegro.
- 46 Netherlands.
- 47 Nepal.
- 48 New Zealand.
- 49 Nigeria.
- 50 Pakistan.
- 51 Poland.
- 52 Portugal.
- 53 Republic of Moldova.
- 54 Romania.
- 55 Russia.
- 56 Saudi Arabia.
- 57 Serbia.
- 58 Spain.
- 59 South Africa.
- 60 South Korea.
- 61 Togo.
- 62 Tunisia.
- 63 Turkey.
- 64 Ukraine.
- 65 United Arab Emirates.
- 66 United Kingdom.
- 67 United States of America.
- 68 Zambia.
- PMID: 36376121
- DOI: 10.1016/j.arbres.2022.09.005
Item in Clipboard
Multicenter Study
Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia
[Article in
English,
Spanish]
Sergi Pascual-Guardia et al.
Arch Bronconeumol.
2023 Feb.
Display options
Format
doi: 10.1016/j.arbres.2022.09.005.
Epub 2022 Sep 22.
Authors
Sergi Pascual-Guardia
1
, Francesco Amati
2
, Judith Marin-Corral
3
, Stefano Aliberti
4
, Joaquim Gea
5
, Nilam J Soni
6
, Alejandro Rodriguez
7
, Oriol Sibila
8
, Francisco Sanz
9
, Giovanni Sotgiu
10
, Pedro J Marcos
11
, Ane Uranga
12
, Branislava Milenkovic
13
, Christian N Meyer
14
, Martin Kolditz
15
, Antonio R Anzueto
6
, Marcos I Restrepo
16
; GLIMP investigators
Collaborators
-
GLIMP investigators:
Patricia Karina Aruj 17 , Silvia Attorri 17 , Enrique Barimboim 17 , Juan Pablo Caeiro 17 , María I Garzón 17 , Victor Hugo Cambursano 17 , Adrian Ceccato 17 , Julio Chertcoff 17 , Florencia Lascar 17 , Fernando Di Tulio 17 , Ariel Cordon Díaz 17 , Lautaro de Vedia 17 , Maria Cristina Ganaha 17 , Sandra Lambert 17 , Gustavo Lopardo 17 , Carlos M Luna 17 , Alessio Gerardo Malberti 17 , Nora Morcillo 17 , Silvina Tartara 17 , Claudia Pensotti 17 , Betiana Pereyra 17 , Pablo Gustavo Scapellato 17 , Juan Pablo Stagnaro 17 , Sonali Shah 18 , Felix Lötsch 19 , Florian Thalhammer 19 , Kurt Anseeuw 20 , Camille A Francois 20 , Eva Van Braeckel 20 , Jean Louis Vincent 20 , Marcel Zannou Djimon 21 , Jules Bashi 21 , Roger Dodo 21 , Simone Aranha Nouér 22 , Peter Chipev 23 , Milena Encheva 23 , Darina Miteva 23 , Diana Petkova 23 , Adamou Dodo Balkissou 24 , Eric Walter Pefura Yone 24 , Bertrand Hugo Mbatchou Ngahane 24 , Ning Shen 25 , Jin-Fu Xu 25 , Carlos Andres Bustamante Rico 26 , Ricardo Buitrago 26 , Fernando Jose Pereira Paternina 26 , Jean-Marie Kayembe Ntumba 27 , Vesna Vladic Carevic 28 , Marko Jakopovic 28 , Mateja Jankovic 28 , Zinka Matkovic 28 , Ivan Mitrecic 28 , Marie-Laure Bouchy Jacobsson 29 , Anette Bro Christensen 29 , Uffe Bødtger 29 , Christian Niels Meyer 29 , Andreas Vestergaard Jensen 29 , Gertrud Baunbæk-Knudsen 29 , Pelle Trier Petersen 29 , Stine Andersen 29 , Ibrahim El-Said Abd El-Wahhab 30 , Nesreen Elsayed Morsy 30 , Hanaa Shafiek 30 , Eman Sobh 30 , Kedir Abdella Abdulsemed 31 , Fabrice Bertrand 32 , Christian Brun-Buisson 32 , Etienne de Montmollin 32 , Muriel Fartoukh 32 , Jonathan Messika 32 , Pierre Tattevin 32 , Abdo Khoury 32 , Bernard Ebruke 33 , Michael Dreher 34 , Martin Kolditz 34 , Matthias Meisinger 34 , Mathias W Pletz 34 , Stefan Hagel 34 , Jan Rupp 34 , Tom Schaberg 34 , Marc Spielmanns 34 , Petra Creutz 34 , Norton Suttorp 34 , Beatrice Siaw-Lartey 35 , Katerina Dimakou 36 , Mina Gaga 36 , Dimosthenis Papapetrou 36 , Evdoxia Tsigou 36 , Dimitrios Ampazis 36 , Evangelos Kaimakamis 36 , Mohit Bhatia 37 , Raja Dhar 37 , George D'Souza 37 , Rajiv Garg 37 , Parvaiz A Koul 37 , P A Mahesh 37 , B S Jayaraj 37 , Kiran Vishnu Narayan 37 , Hirennappa B Udnur 37 , Shashi Bhaskara Krishnamurthy 37 , Surya Kant 37 , Rajesh Swarnakar 37 , Sneha Limaye 37 , Sundeep Salvi 37 , Keihan Golshani 38 , Vera M Keatings 39 , Ignacio Martin-Loeches 39 , Yasmin Maor 40 , Jacob Strahilevitz 40 , Salvatore Battaglia 41 , Maria Carrabba 41 , Piero Ceriana 41 , Marco Confalonieri 41 , Antonella d'Arminio Monforte 41 , Bruno Del Prato 41 , Marino De Rosa 41 , Riccardo Fantini 41 , Paola Faverio 41 , Giuseppe Fiorentino 41 , Maria Antonia Gammino 41 , Francesco Menzella 41 , Giuseppe Milani 41 , Stefano Nava 41 , Gerardo Palmiero 41 , Roberta Petrino 41 , Barbara Gabrielli 41 , Paolo Rossi 41 , Claudio Sorino 41 , Gundi Steinhilber 41 , Alessandro Zanforlin 41 , Fabio Franzetti 41 , Manuela Carugati 41 , Manuela Morosi 41 , Elisa Monge 41 , Mauro Carone 41 , Vincenzo Patella 41 , Simone Scarlata 41 , Andrea Comel 41 , Kiyoyasu Kurahashi 42 , Zeina Aoun Bacha 43 , Daniel Barajas Ugalde 44 , Omar Ceballos Zuñiga 44 , José F Villegas 44 , Milic Medenica 45 , E M W van de Garde 46 , Deebya Raj Mihsra 47 , Poojan Shrestha 47 , Elliott Ridgeon 48 , Babatunde Ishola Awokola 49 , Ogonna N O Nwankwo 49 , Adefuye Bolanle Olufunlola 49 , Segaolu Olumide 49 , Kingsley N Ukwaja 49 , Muhammad Irfan 50 , Lukasz Minarowski 51 , Skoczyński Szymon 51 , Felipe Froes 52 , Pedro Leuschner 52 , Mariana Meireles 52 , Cláudia Ferrão 52 , João Neves 52 , Sofia B Ravara 52 , Victoria Brocovschii 53 , Chesov Ion 53 , Doina Rusu 53 , Cristina Toma 53 , Daniela Chirita 54 , Carmen Mihaela Dorobat 54 , Alexei Birkun 55 , Anna Kaluzhenina 55 , Abdullah Almotairi 56 , Zakeya Abdulbaqi Ali Bukhary 56 , Jameela Edathodu 56 , Amal Fathy 56 , Abdullah Mushira Abdulaziz Enani 56 , Nazik Eltayeb Mohamed 56 , Jawed Ulhadi Memon 56 , Abdelhaleem Bella 56 , Nada Bogdanović 57 , Branislava Milenkovic 57 , Dragica Pesut 57 , Luis Borderìas 58 , Noel Manuel Bordon Garcia 58 , Hugo Cabello Alarcón 58 , Catia Cilloniz 58 , Antoni Torres 58 , Vicens Diaz-Brito 58 , Xavier Casas 58 , Alicia Encabo González 58 , Maria Luisa Fernández-Almira 58 , Miguel Gallego 58 , Inmaculada Gaspar-García 58 , Juan González Del Castillo 58 , Patricia Javaloyes Victoria 58 , Elena Laserna Martínez 58 , Rosa Malo de Molina 58 , Pedro J Marcos 58 , Rosario Menéndez 58 , Ana Pando-Sandoval 58 , Cristina Prat Aymerich 58 , Alicia Lacoma de la Torre 58 , Ignasi García-Olivé 58 , Jordi Rello 58 , Silvia Moyano 58 , Francisco Sanz 58 , Oriol Sibila 58 , Ana Rodrigo-Troyano 58 , Jordi Solé-Violán 58 , Ane Uranga 58 , Job F M van Boven 58 , Ester Vendrell Torra 58 , Jordi Almirall Pujol 58 , Charles Feldman 59 , Ho Kee Yum 60 , Arnauld Attannon Fiogbe 61 , Ferdaous Yangui 62 , Semra Bilaceroglu 63 , Levent Dalar 63 , Ufuk Yilmaz 63 , Artemii Bogomolov 64 , Naheed Elahi 65 , Devesh J Dhasmana 66 , Andrew Feneley 66 , Rhiannon Ions 66 , Julie Skeemer 66 , Gerrit Woltmann 66 , Carole Hancock 66 , Adam T Hill 66 , Banu Rudran 66 , Silvia Ruiz-Buitrago 66 , Marion Campbell 66 , Paul Whitaker 66 , Alexander Youzguin 66 , Anika Singanayagam 66 , Karen S Allen 67 , Veronica Brito 67 , Jessica Dietz 67 , Claire E Dysart 67 , Susan M Kellie 67 , Ricardo A Franco-Sadud 67 , Garnet Meier 67 , Thomas L Holland 67 , Stephen P Bergin 67 , Fayez Kheir 67 , Mark Landmeier 67 , Manuel Lois 67 , Girish B Nair 67 , Hemali Patel 67 , Katherine Reyes 67 , William Rodriguez-Cintron 67 , Shigeki Saito 67 , Nilam J Soni 67 , Julio Noda 67 , Cecilia I Hinojosa 67 , Stephanie M Levine 67 , Luis F Angel 67 , Luis F Reyes 67 , Antonio Anzueto 67 , K Scott Whitlow 67 , John Hipskind 67 , Kunal Sukhija 67 , Vicken Totten 67 , Richard G Wunderink 67 , Ray D Shah 67 , Kondwelani John Mateyo 68 , Lorena Noriega, Ezequiel Alvarado, Mohamed Aman, Lucía Labra
Affiliations
- 1 Respiratory Department, Hospital del Mar-IMIM, CEXS, UPF, CIBERES, BRN, Barcelona, Spain; Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA.
- 2 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy.
- 3 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Critical Care Department, Hospital del Mar-IMIM, Critical Illness Research Group (GREPAC), Barcelona,Spain.
- 4 Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy.
- 5 Respiratory Department, Hospital del Mar-IMIM, CEXS, UPF, CIBERES, BRN, Barcelona, Spain.
- 6 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Section of Pulmonary & Critical Care Medicine, South Texas Veterans Health Care System,USA.
- 7 Critical Care Department, Hospital Universitari Joan XXIII, URV, CIBERES, Tarragona, Spain.
- 8 Respiratory Department, Hospital Clinic, CIBERES, BRN, Barcelona, Spain.
- 9 Pulmonology Department, Consorci Hospital General Universitari de Valencia, Valencia,Spain.
- 10 Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari,Italy.
- 11 Servicio de Neumología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC) Sergas Universidade da Coruña (UDC),A Coruña,Spain.
- 12 Pulmonology Department, Hospital of Galdakao-Usansolo,Spain.
- 13 Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade,Serbia.
- 14 Department of Internal Medicine, Roskilde Hospital, Copenhagen University Hospital, Roskilde,Denmark.
- 15 Division of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus, Technische Universität Dresden,Germany.
- 16 Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX,USA; Section of Pulmonary & Critical Care Medicine, South Texas Veterans Health Care System,USA. Electronic address: restrepom@uthscsa.edu.
- 17 Argentina.
- 18 Australia.
- 19 Austria.
- 20 Belgium.
- 21 Benin.
- 22 Brazil.
- 23 Bulgaria.
- 24 Cameroon.
- 25 China.
- 26 Colombia.
- 27 Congo.
- 28 Croatia.
- 29 Denmark.
- 30 Egypt.
- 31 Ethiopia.
- 32 France.
- 33 Gambia.
- 34 Germany.
- 35 Ghana.
- 36 Greece.
- 37 India.
- 38 Iran.
- 39 Ireland.
- 40 Israel.
- 41 Italy.
- 42 Japan.
- 43 Lebanon.
- 44 Mexico.
- 45 Montenegro.
- 46 Netherlands.
- 47 Nepal.
- 48 New Zealand.
- 49 Nigeria.
- 50 Pakistan.
- 51 Poland.
- 52 Portugal.
- 53 Republic of Moldova.
- 54 Romania.
- 55 Russia.
- 56 Saudi Arabia.
- 57 Serbia.
- 58 Spain.
- 59 South Africa.
- 60 South Korea.
- 61 Togo.
- 62 Tunisia.
- 63 Turkey.
- 64 Ukraine.
- 65 United Arab Emirates.
- 66 United Kingdom.
- 67 United States of America.
- 68 Zambia.
- PMID: 36376121
- DOI: 10.1016/j.arbres.2022.09.005
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Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is strongly associated with the development of community-acquired pneumonia (CAP). Limited data are available on risk factors for difficult to manage bacteria such as Pseudomonas aeruginosa in COPD patients with CAP. Our objective was to assess the microbiological patterns associated with risk factors that determine empiric antibiotic therapy in hospitalized COPD patients with CAP.
Methods: We performed a secondary data analysis of an international, multicenter, observational, point-prevalence study involving hospitalized COPD patients with CAP from March to June 2015. After identifying the risk factors associated with different microorganisms, we developed a scoring system to guide decision-making about empiric anti-pseudomonal antibiotic therapy in this population.
Results: We enrolled 689 hospitalized COPD patients with CAP with documented microbiological testing. The most frequent microorganisms isolated were Streptococcus pneumoniae (8%) and Gram-negative bacteria (8%), P. aeruginosa (7%) and Haemophilus influenzae (3%). We developed a scoring system incorporating the variables independently associated with P. aeruginosa that include a previous P. aeruginosa isolation or infection (OR 14.2 [95%CI 5.7-35.2]), hospitalization in the past 12 months (OR 3.7 [1.5-9.2]), and bronchiectasis (OR 3.2 [1.4-7.2]). Empiric anti-pseudomonal antibiotics were overutilized in COPD patients with CAP. The new scoring system has the potential to reduce empiric anti-pseudomonal antibiotic use from 54.1% to 6.2%.
Conclusions: COPD patients with CAP present different microbiological profiles associated with unique risk factors. Anti-pseudomonal treatment is a critical decision when selecting empiric antibiotic therapy. We developed a COPD scoring system to guide decision-making about empiric anti-pseudomonal antibiotic therapy.
Keywords: Anti-bacterial agents; Antibiotics; COPD; Pseudomonas; Risk factors.
Published by Elsevier España, S.L.U.
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