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Review
. 2023 Feb;51(2):265-272.
doi: 10.1002/jcu.23392. Epub 2022 Nov 15.

An update on maternal cardiac hemodynamics in fetal growth restriction and pre-eclampsia

Andrea Dall'Asta  1 , Monica Minopoli  1 , Ruben Ramirez Zegarra  1 , Elvira Di Pasquo  1 , Tullio Ghi  1
Affiliations
Review

An update on maternal cardiac hemodynamics in fetal growth restriction and pre-eclampsia

Andrea Dall'Asta et al. J Clin Ultrasound. 2023 Feb.

Abstract

Pre-eclampsia and fetal growth restriction (FGR) have been long related to primary placental dysfunction, caused by abnormal trophoblast invasion. Nevertheless, emerging evidence has led to a new hypothesis for the origin of pre-eclampsia and FGR. Suboptimal maternal cardiovascular adaptation has been shown to result in uteroplacental hypoperfusion, ultimately leading to placental hypoxic damage with secondary dysfunction. In this review, we summarize current evidence on maternal cardiac hemodynamics in FGR and pre-eclampsia. We also discuss the different approaches for antihypertensive treatment according to the hemodynamic phenotype observed in pre-eclampsia and FGR.

Keywords: cardiac output; cardiovascular adaptation; fetal growth restriction; peripheral vascular resistance; pre-eclampsia.

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References

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