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Comment
. 2022 Nov 14;40(11):1270-1272.
doi: 10.1016/j.ccell.2022.10.014.

Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?

Kylee H Maclachlan  1 , Alexander M Lesokhin  2
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Free article
Comment

Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?

Kylee H Maclachlan et al. Cancer Cell. .
Free article

Abstract

Sklavenitis-Pistofidis et al. report clinical and correlative results of a single-arm phase II trial of elotuzumab, lenalidomide, and dexamethasone in patients with high-risk smoldering myeloma. The authors explore the interactions between the genetics of the plasma cell clone and the immune microenvironment as potential biomarkers of treatment susceptibility and efficacy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.
    Sklavenitis-Pistofidis R, Aranha MP, Redd RA, Baginska J, Haradhvala NJ, Hallisey M, Dutta AK, Savell A, Varmeh S, Heilpern-Mallory D, Ujwary S, Zavidij O, Aguet F, Su NK, Lightbody ED, Bustoros M, Tahri S, Mouhieddine TH, Wu T, Flechon L, Anand S, Rosenblatt JM, Zonder J, Vredenburgh JJ, Boruchov A, Bhutani M, Usmani SZ, Matous J, Yee AJ, Jakubowiak A, Laubach J, Manier S, Nadeem O, Richardson P, Badros AZ, Mateos MV, Trippa L, Getz G, Ghobrial IM. Sklavenitis-Pistofidis R, et al. Cancer Cell. 2022 Nov 14;40(11):1358-1373.e8. doi: 10.1016/j.ccell.2022.10.017. Cancer Cell. 2022. PMID: 36379208 Free PMC article.

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