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Comment
. 2022 Nov 14;40(11):1273-1275.
doi: 10.1016/j.ccell.2022.10.018.

What's in a name? An emerging framework for cancer-associated fibroblasts, myofibroblasts, and fibroblasts

Shakir Hasan  1 , Matthew B Buechler  2
Affiliations
Comment

What's in a name? An emerging framework for cancer-associated fibroblasts, myofibroblasts, and fibroblasts

Shakir Hasan et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Foster and colleagues explore the heterogeneity in cancer-associated fibroblasts (CAFs) across tissue types and species, and they identify mechanoresponsive (MR), immunomodulatory (IM), and steady-state-like (SSL) CAFs. They show that altering the relative abundance of these CAF subtypes influences tumor progression and response to anti-tumor therapy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.
    Foster DS, Januszyk M, Delitto D, Yost KE, Griffin M, Guo J, Guardino N, Delitto AE, Chinta M, Burcham AR, Nguyen AT, Bauer-Rowe KE, Titan AL, Salhotra A, Jones RE, da Silva O, Lindsay HG, Berry CE, Chen K, Henn D, Mascharak S, Talbott HE, Kim A, Nosrati F, Sivaraj D, Ransom RC, Matthews M, Khan A, Wagh D, Coller J, Gurtner GC, Wan DC, Wapnir IL, Chang HY, Norton JA, Longaker MT. Foster DS, et al. Cancer Cell. 2022 Nov 14;40(11):1392-1406.e7. doi: 10.1016/j.ccell.2022.09.015. Epub 2022 Oct 20. Cancer Cell. 2022. PMID: 36270275 Free PMC article.

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