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. 2022 Nov 15;7(1):147.
doi: 10.1038/s41541-022-00565-y.

Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant

Ioannis Sitaras #  1 , Henning Jacobsen #  2 , Melissa M Higdon  3 , William E Dowling  4 , Naor Bar-Zeev  3 , Maria Deloria Knoll  3
Affiliations

Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant

Ioannis Sitaras et al. NPJ Vaccines. .

Abstract

Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.

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Conflict of interest statement

M.M.H. reports research grants from Pfizer for unrelated work; M.D.K. reports research grants from Pfizer and Merck and consultancy fees from Merck, all for unrelated work; N.B.Z. reports research grants from Merck, from Johnson & Johnson and from Serum Institute of India, all for unrelated work; and consulting fees from Merck for unrelated work. The rest of the authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Primary vaccination series and booster neutralizing ability and percent responders against Omicron.
Neutralizing ability of antibodies against Omicron variant by vaccine as measured by A: fold reduction post-primary series vaccination; B: fold reduction post-booster vaccination; C: percent of responders post-primary; D: percent of responders post-booster. Thick lines represent median, thin lines represent interquartile range (IQR).
Fig. 2
Fig. 2. PRISMA flow diagram.
Overview of the systematic literature search and study selection process.
See this image and copyright information in PMC

References

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    1. ECDC. SARS-CoV-2 Variants Dashboard, https://www.ecdc.europa.eu/en/covid-19/situation-updates/variants-dashboard (2022).
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    1. Yu X, et al. Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination. Cell Discov. 2022;8:4. doi: 10.1038/s41421-022-00375-5. - DOI - PMC - PubMed
    1. Jacobsen, H. et al. Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations. Preprint at https://www.medrxiv.org/content/10.1101/2021.12.21.21267898v1 (2021). - DOI - PMC - PubMed