Independent effects of acute normobaric hypoxia and hypobaric hypoxia on human physiology

Abstract

The purpose of this study was to examine the effects of acute normobaric (NH, decreased FiO₂) and hypobaric (HH, 4200 m ascent) hypoxia exposures compared to sea level (normobaric normoxia, NN). Tissue oxygenation, cardiovascular, and body fluid variables measured during rest and a 3-min step-test following 90-min exposures (NH, HH, NN). Muscle oxygenated hemoglobin (O₂Hb) decreased, and muscle deoxygenated hemoglobin (HHb) increased environmentally independent from rest to exercise (p < 0.001). During exercise, brain O₂Hb was lower at HH compared to NN (p = 0.007), trending similarly with NH (p = 0.066), but no difference between NN and NH (p = 0.158). During exercise, HR at NH (141 ± 4 beats·min^-1) and HH (141 ± 3 beats·min^-1) were higher than NN (127 ± 44 beats·min^-1, p = 0.002), but not each other (p = 0.208). During exercise, stroke volume at HH (109.6 ± 4.1 mL·beat^-1) was higher than NH (97.8 ± 3.3 mL·beat^-1) and NN (99.8 ± 3.9 mL·beat^-1, p ≤ 0.010) with no difference between NH and NN (p = 0.481). During exercise, cardiac output at NH (13.8 ± 0.6 L) and HH (15.5 ± 0.7 L) were higher than NN (12.6 ± 0.5 L, p ≤ 0.006) with HH also higher than NH (p = 0.001). During acute hypoxic stimuli, skeletal muscle maintains oxygenation whereas the brain does not. These differences may be mediated by environmentally specific cardiovascular compensation. Thus, caution is advised when equating NH and HH.

Figure 1

(a) Muscle oxygenated (O₂Hb) and (b) deoxygenated (HHb) hemoglobin concentration change at normobaric normoxia (NN), normobaric hypoxia (NH), and hypobaric hypoxia (HH) during rest and exercise expressed relative to daily pre-environmental exposure at NN. *p < 0.05 from Rest. †p < 0.05 from NN. Data presented as means ± SE.

Figure 2

(a) Brain oxygenated (O₂HB) and (b) deoxygenated (HHb) hemoglobin concentration change at normobaric normoxia (NN), normobaric hypoxia (NH), and hypobaric hypoxia (HH) during rest and exercise expressed relative to daily pre-environmental exposure at NN.*p < 0.05 from Rest at NN. †p < 0.05 from Exercise at NN. ‡p < 0.05 from Rest. §p < 0.05 from NN. Data presented as means ± SE.