Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;73(12):965-972.
doi: 10.1007/s00105-022-05071-9. Epub 2022 Nov 15.

[Eosinophilic dermatoses]

[Article in German]
E Papakonstantinou  1 , J Fischer  2   3 , M M Limberg  2 , G F H Diercks  4 , B Horvath  4 , U Raap  5   6
Affiliations

[Eosinophilic dermatoses]

[Article in German]
E Papakonstantinou et al. Dermatologie (Heidelb). 2022 Dec.

Abstract
in English, German

Eosinophilic dermatoses are a heterogeneous group of rare diseases that histopathologically display the defining pattern of an eosinophil-rich dermal infiltrate. In these eosinophilic dermatoses, a histopathologic pattern called flame figures, which result from degranulation of eosinophils in the tissue, can be observed. Although eosinophil granulocytes can also be detected in other dermatoses such as atopic dermatitis, urticaria, prurigo and bullous pemphigoid, the eosinophil-rich infiltrate is decisive for classic eosinophilic dermatoses. Accordingly, eosinophilic dermatoses include hypereosinophilic syndrome, eosinophilic fasciitis, granuloma faciale, pustular sterile eosinophilia, and angiolymphoid hyperplasia with eosinophilia. These eosinophilic dermatoses display clinical different patterns and are discussed in this article, as well as the interesting eosinophils and novel therapeutic options.

Die eosinophilen Dermatosen sind eine heterogene Gruppe von seltenen Krankheiten, die histopathologisch das entscheidende Muster eines eosinophilenreichen dermalen Infiltrates vorweisen. Bei diesen eosinophilen Dermatosen können histopathologisch Flammenfiguren nachgewiesen werden, die durch die Degranulation der Eosinophilen im Gewebe entstehen. Wenngleich eosinophile Granulozyten auch bei anderen Dermatosen wie der atopischen Dermatitis, der Urtikaria, der Prurigo und dem bullösen Pemphigoid etc. nachgewiesen werden können, so ist das eosinophilenreiche Infiltrat für die klassischen eosinophilen Dermatosen ausschlaggebend. Zu den eosinophilen Dermatosen im engeren Sinn gehören das hypereosinophile Syndrom, die eosinophile Fasziitis, das Granuloma faciale, die pustulöse sterile Eosinophilie und die angiolymphoide Hyperplasie mit Eosinophilie. Diese eosinophilen Dermatosen weisen ein unterschiedliches klinisches Bild auf und werden in diesem Beitrag zusammen mit den interessanten eosinophilen Granulozyten sowie neuen Therapieoptionen vorgestellt.

Keywords: Anti-interleukin‑5; Eosinophil granulocytes; Eosinophil-rich infiltrate; Flame figures; Hypereosinophilia.

PubMed Disclaimer

References

Literatur

    1. Dunn JLM, Rothenberg ME (2022) 2021 year in review: Spotlight on eosinophils. J Allergy Clin Immunol 149(2):517–524 - DOI - PubMed
    1. Pepper AN et al (2021) How to assess effectiveness of biologics for asthma and what steps to take when there is not benefit. J Allergy Clin Immunol Pract 9(3):1081–1088 - DOI - PubMed
    1. Kim CK et al (2022) Increase in eosinophil-derived neurotoxin level in school children with allergic disease. Asia Pac Allergy 12(3):e25 - DOI - PubMed - PMC
    1. Makiya MA et al (2022) Urine eosinophil-derived neurotoxin: a potential marker of activity in select eosinophilic disorders. Allergy. https://doi.org/10.1111/all.15481 - DOI
    1. Ruppenstein A et al (2021) Involvement of neuro-immune interactions in pruritus with special focus on receptor expressions. Front Med 8:627985 - DOI

Publication types

LinkOut - more resources