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Clinical Trial
. 2023 Apr 17;76(8):1500-1503.
doi: 10.1093/cid/ciac894.

Cardiovascular Outcomes After Tixagevimab and Cilgavimab use for Pre-Exposure Prophylaxis Against Coronavirus Disease 2019: A Population-Based Propensity-matched Cohort Study

Morgan Birabaharan  1 , Eddie Hill  1 , Maedha Begur  1 , David C Kaelber  2   3 , Thomas C S Martin  1   4 , Sanjay R Mehta  1   4
Affiliations
Clinical Trial

Cardiovascular Outcomes After Tixagevimab and Cilgavimab use for Pre-Exposure Prophylaxis Against Coronavirus Disease 2019: A Population-Based Propensity-matched Cohort Study

Morgan Birabaharan et al. Clin Infect Dis. .

Abstract

Tixagevimab and cilgavimab treatment was associated with higher rates of cardiovascular events in a post hoc analysis of a phase 3 trial. In this large population-based propensity-matched study, we found no increased risk of cardiovascular events up to 90 days after tixagevimab and cilgavimab administration, including in patients with pre-existing cardiovascular disease.

Keywords: COVID 19; cardiovascular; cilgavimab; evusheld; tixagevimab.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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