Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb;38(1-2):85-102.
doi: 10.1177/08830738221120741. Epub 2022 Nov 15.

A Scoping Review of Magnetic Resonance Modalities Used in Detection of Persistent Postconcussion Symptoms in Pediatric Populations

Elena Sheldrake  1   2 , Brendan Lam  1 , Hiba Al-Hakeem  1 , Anne L Wheeler  3   4 , Benjamin I Goldstein  5   6   7 , Benjamin T Dunkley  3   8 , Stephanie Ameis  5   7   8 , Nick Reed  2 , Shannon E Scratch  1   2   9
Affiliations

A Scoping Review of Magnetic Resonance Modalities Used in Detection of Persistent Postconcussion Symptoms in Pediatric Populations

Elena Sheldrake et al. J Child Neurol. 2023 Feb.

Abstract

Up to 30% of youth with concussion experience PPCSs (PPCS) lasting 4 weeks or longer, and can significantly impact quality of life. Magnetic resonance imaging (MRI) has the potential to increase understanding of causal mechanisms underlying PPCS. However, there are no clear modalities to assist in detecting PPCS. This scoping review aims to synthesize findings on utilization of MRI among children and youth with PPCS, and summarize progress and limitations. Thirty-six studies were included from 4907 identified papers. Many studies used multiple modalities, including (1) structural (n = 27) such as T1-weighted imaging, diffusion weighted imaging, and susceptibility weighted imaging; and (2) functional (n = 23) such as functional MRI and perfusion-weighted imaging. Findings were heterogeneous among modalities and regions of interest, which warrants future reviews that report on the patterns and potential advancements in the field. Consideration of modalities that target PPCS prediction and sensitive modalities that can supplement a biopsychosocial approach to PPCS would benefit future research.

Keywords: MRI; children; concussion; neuroimaging; pediatric.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
PRISMA diagram.
See this image and copyright information in PMC

References

    1. Hon KL, Leung AKC, Torres AR. Concussion: A global perspective. Semin Pediatr Neurol. 2019;30:117-127. - PubMed
    1. Veliz P, McCabe SE, Eckner JT, et al.. Trends in the prevalence of concussion reported by US adolescents, 2016–2020. JAMA. 2016;34(17):376-378. - PMC - PubMed
    1. Gordon KE, Dooley JM, Wood EP. Descriptive epidemiology of concussion. Pediatr Neurol. 2006;34(5):376-378. - PubMed
    1. Hadanny A, Efrati S. Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions. Expert Rev Neurother. 2006;16(8):875-887. - PubMed
    1. Dufour SC, Adams RS, Brody DL. et al.. Prevalence and correlates of concussion of concussion in children: data from the adolescent brain cognitive development study. Cortex. 2020;131:237-250. - PubMed

Publication types