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. 2022 Nov 12;24(Suppl I):I16-I21.
doi: 10.1093/eurheartjsupp/suac098. eCollection 2022 Nov.

Transcatheter mitral valve replacement: there is still work to be done

Antonio L Bartorelli  1   2 , Giovanni Monizzi  1 , Angelo Mastrangelo  1 , Luca Grancini  1 , Franco Fabbiocchi  1 , Edoardo Conte  1   3 , Marco Moltrasio  1 , Daniele Andreini  1   2
Affiliations

Transcatheter mitral valve replacement: there is still work to be done

Antonio L Bartorelli et al. Eur Heart J Suppl. .

Abstract

Transcatheter mitral valve replacement (TMVR) is a novel therapeutic option for patients with severe mitral regurgitation (MR) at high or prohibitive surgical risk. Most TMVR technologies under investigation use either a trans-apical or a trans-septal approach via dedicated multistep anchoring systems. Transcatheter mitral valve replacement offers several potential advantages over transcatheter repair, notably a greater and more sustained MR reduction. At the same time, significant engineering challenges and potential disadvantages must be acknowledged. Preclinical and clinical studies have shown promising results, demonstrating TMVR feasibility. Nevertheless, further development, testing, and trials are needed before considering TMVR as a definitive therapeutic option for MR in a wide range of anatomical scenarios.

Keywords: Mitral regurgitation; Mitral valve; Transcatheter mitral valve replacement.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Transcatheter mitral valve replacement (TMVR) systems in clinical evaluation.
See this image and copyright information in PMC

References

    1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. L`ancet 2006;368:1005–1011. - PubMed
    1. Agricola E, Ielasi A, Oppizzi M, Faggiano P, Ferri L, Calabrese Aet al. . Long-term prognosis of medically treated patients with functional mitral regurgitation and left ventricular dysfunction. Eur J Heart Fail 2009;11:581–587. - PubMed
    1. Goel SS, Bajaj N, Aggarwal Bet al. . Prevalence and outcomes of unoperated patients with severe symptomatic mitral regurgitation and heart failure: comprehensive analysis to determine the potential role of mitraclip for this unmet need. J Am Coll Cardiol 2014;63:185–186. - PubMed
    1. Vahanian A, Alfieri O, Andreotti F, Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology, European Association for Cardio-Thoracic . et al. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 2012;33:2451–2496. - PubMed
    1. Sorajja P, Vemulapalli S, Feldman Tet al. . Outcomes with transcatheter mitral valve repair in the United States: an STS/ACC TVT registry report. J Am Coll Cardiol 2017;70:2315–2327. - PubMed