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. 2022 Oct 28;9(11):ofac558.
doi: 10.1093/ofid/ofac558. eCollection 2022 Nov.

Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Adrià Ramírez Mena  1   2   3 , Mame Aissé Thioubou  4 , Kalilou Diallo  5 , Judicaël Tine  1 , Ndeye Fatou Ngom  6 , Louise Fortes  1 , Kiné Ndiaye  6 , Jean-Claude Karasi  7 , Carole Seguin-Devaux  8 , Henri Goedertz  7 , Daouda Diouf  9 , Moussa Seydi  1 , Benjamin Amaye Sambou  9 , Vic Arendt  7 , Gilles Wandeler  1   2   10 , Noël Magloire Manga  5 ; for SEN-B and CARES
Affiliations

Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Adrià Ramírez Mena et al. Open Forum Infect Dis. .

Abstract

The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

Keywords: Senegal; hepatitis B; liver fibrosis.

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Figures

Figure 1.
Figure 1.
Chronic hepatitis B marker assessment (A) and antiviral treatment eligibility according to European Association for the Study of the Liver recommendations (B) among people with hepatitis B virus in Senegal, by sex. Abbreviations: ALT, alanine aminotransferase; HBV, hepatitis B virus.
See this image and copyright information in PMC

References

    1. World Health Organization . Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection.2015. https://apps.who.int/iris/handle/10665/154590. Accessed 24 August 2022.
    1. Ramírez Mena A, Tine JM, Fortes L, et al. . Hepatitis B screening practices and viral control among persons living with HIV in urban Senegal. J Viral Hepat 2022; 29:60–8. - PMC - PubMed
    1. Surial B, Wyser D, Béguelin C, Ramírez-Mena A, Rauch A, Wandeler G. Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: systematic review and meta-analysis. Liver Int 2021; 41:710–9. - PMC - PubMed
    1. Tan M, Bhadoria AS, Cui F, et al. . Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2021; 6:106–19. - PMC - PubMed
    1. Lampertico P, Agarwal K, Berg T, et al. . EASL 2017 Clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol 2017; 67:370–98. - PubMed