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. 2023 Jan 6;51(D1):D539-D545.
doi: 10.1093/nar/gkac1015.

CORUM: the comprehensive resource of mammalian protein complexes-2022

George Tsitsiridis  1 , Ralph Steinkamp  1 , Madalina Giurgiu  2 , Barbara Brauner  1 , Gisela Fobo  1 , Goar Frishman  1 , Corinna Montrone  1 , Andreas Ruepp  1
Affiliations

CORUM: the comprehensive resource of mammalian protein complexes-2022

George Tsitsiridis et al. Nucleic Acids Res. .

Abstract

The CORUM database has been providing comprehensive reference information about experimentally characterized, mammalian protein complexes and their associated biological and biomedical properties since 2007. Given that most catalytic and regulatory functions of the cell are carried out by protein complexes, their composition and characterization is of greatest importance in basic and disease biology. The new CORUM 4.0 release encompasses 5204 protein complexes offering the largest and most comprehensive publicly available dataset of manually curated mammalian protein complexes. The CORUM dataset is built from 5299 different genes, representing 26% of the protein coding genes in humans. Complex information from 3354 scientific articles is mainly obtained from human (70%), mouse (16%) and rat (9%) cells and tissues. Recent curation work includes sets of protein complexes, Functional Complex Groups, that offer comprehensive collections of published data in specific biological processes and molecular functions. In addition, a new graphical analysis tool was implemented that displays co-expression data from the subunits of protein complexes. CORUM is freely accessible at http://mips.helmholtz-muenchen.de/corum/.

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Figures

Figure 1.
Figure 1.
Data growth in CORUM. The plot compares the data content of CORUM versions 1.0, 2.0, 3.0 and 4.0. It includes the number of articles that were used to create the datasets, the total number of protein complexes as well as the total number of different proteins that are found in the dataset.
Figure 2.
Figure 2.
Reuse of proteins in mammalian protein complexes. The number of proteins (y-axis) participating in a particular number of complexes (x-axis) is plotted. There are for example 740 proteins, which are subunits in three protein complexes in the CORUM 4.0 dataset.
Figure 3.
Figure 3.
Dataset of functional complex groups (FCGs) in CORUM. The homepage shows available FCGs and the respective number of members.
Figure 4.
Figure 4.
Co-expression of the immunoproteasome subunits shown on the CORUM interface for gene co-expression. At a significance score of 0.8, subunits which are specific for the immunoproteasome form a cluster that is separated from subunits of the constitutive proteasome. All protein complex entries where the respective information is available, are linked to a co-expression interface.
See this image and copyright information in PMC

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