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. 2023 Mar;36(2):252-258.
doi: 10.1111/pcmr.13075. Epub 2022 Dec 7.

Database for queries of melanoma cohorts with molecular and clinical data

Manuel Philip  1 , Sven Holger Puppel  2 , Mathias Stiller  3 , Annette Paschen  1 , Alexander Roesch  1 , Anne Zaremba  1 , Dirk Schadendorf  1 , Susanne Horn  1   2
Affiliations

Database for queries of melanoma cohorts with molecular and clinical data

Manuel Philip et al. Pigment Cell Melanoma Res. 2023 Mar.

Abstract

Large genome-scale studies are deposited in various public sequence repositories. However, their access and analysis can be non-trivial to infrequent users. Here, we present a new database connecting whole transcriptomes with clinical data for straight-forward access and analysis of patient-specific samples. Users can perform association tests of survival and gene expression across different cohorts, identify cell-type expressions, or correlate the presence of immune cells. In summary, we present a new data hub for bench scientists to perform replication and discovery studies.

Keywords: RNA-seq; data integration; immune checkpoint inhibition; immune infiltration; melanoma.

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References

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