Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection
- PMID: 36384088
- PMCID: PMC9729816
- DOI: 10.1016/j.xcrm.2022.100809
Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection
Abstract
Bharadwaj et al.1 demonstrate that anti-donor HLA antibodies display low levels of Fc fucosylation. This signature was associated with potent provocation of NK cell effector functions and was discriminative for active antibody-mediated rejection among patients with donor specific HLA antibodies.
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation.Cell Rep Med. 2022 Nov 15;3(11):100818. doi: 10.1016/j.xcrm.2022.100818. Cell Rep Med. 2022. PMID: 36384101 Free PMC article.
References
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