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Comment
. 2022 Nov 15;3(11):100807.
doi: 10.1016/j.xcrm.2022.100807.

The mechanism of bone repair: Stem cells in the periosteum dedicated to bridging a large gap

Noriaki Ono  1
Affiliations
Comment

The mechanism of bone repair: Stem cells in the periosteum dedicated to bridging a large gap

Noriaki Ono. Cell Rep Med. .

Abstract

Bone repair requires the mobilization of stem cells from outer periosteum and inner bone marrow. A study by Jeffery et al.1 shows that periosteal stem cells are dedicated to repairing a large defect and regenerating both bone and marrow stroma.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Figures

Figure 1
Figure 1
Gli1+ periosteal skeletal stem cells for repairing large bone fractures Under steady-state conditions or small injuries, new bone is made by Adiponectin+ cells in bone marrow. Gli1+ periosteal cells are reserved for repairing extensive large bicortical fractures involving fibrocartilage and produce Adipoq+ cells in bone marrow after healing. Created by BioRender.com.
See this image and copyright information in PMC

Comment on

References

    1. Jeffery E.C., Mann T.L.A., Pool J.A., Zhao Z., Morrison S.J. Bone marrow and periosteal stem/progenitor cells make distinct contributions to bone maintenance and repair. Cell Stem Cell. 2022 - PubMed
    1. Colnot C. Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J Bone Miner Res. Feb. 2009;24:274–282. doi: 10.1359/jbmr.081003. - DOI - PMC - PubMed
    1. Matthews B.G., Grcevic D., Wang L., Hagiwara Y., Roguljic H., Joshi P., Shin D.G., Adams D.J., Kalajzic I. Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing. J. Bone Miner. Res. 2014;29:1283–1294. doi: 10.1002/jbmr.2140. - DOI - PMC - PubMed
    1. Duchamp de Lageneste O., Julien A., Abou-Khalil R., Frangi G., Carvalho C., Cagnard N., Cordier C., Conway S.J., Colnot C. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat Commun. 02. 2018;9:773. doi: 10.1038/s41467-018-03124-z. - DOI - PMC - PubMed
    1. Debnath S., Yallowitz A.R., McCormick J., Lalani S., Zhang T., Xu R., Li N., Liu Y., Yang Y.S., Eiseman M., et al. Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. Oct. 2018;562:133–139. doi: 10.1038/s41586-018-0554-8. - DOI - PMC - PubMed