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Case Reports
. 2022 Nov 1:2022:3785713.
doi: 10.1155/2022/3785713. eCollection 2022.

Disseminated Mycobacterium Tuberculosis and IgA Nephropathy

Gordon Audley  1 , Bianca Davidson  2 , Erika Jones  2 , Brendon Price  3 , Brian Rayner  2 , Nicola Wearne  2 , Zibya Barday  2
Affiliations
Case Reports

Disseminated Mycobacterium Tuberculosis and IgA Nephropathy

Gordon Audley et al. Case Rep Nephrol. .

Abstract

Mycobacterium tuberculosis (MTB) is an under-recognised cause of genitourinary disease. IgA nephropathy (IgAN), a leading cause of glomerulonephritis worldwide, has been described as a rare consequence of disseminated MTB infection. In this case report, we present the first case of MTB associated IgAN in Africa. Finding IgAN on kidney biopsy in an MTB endemic area should prompt a thorough investigation for MTB to increase the chance of remission of IgAN and prevent inappropriate use of immunosuppression.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Right hallux non-healing ulcer, (b) chest radiograph, and (c) magnetic resonance imaging (MRI) of the thoracic spine.
Figure 2
Figure 2
(a) Periodic acid-Schiff stained paraffin sections showing mesangial hypercellularity (arrow) and a focal cellular crescent (star) (x 100). (b) Higher magnification of glomerulus exhibiting mesangial hypercellularity (arrow) (x 400). (C) and (D) Immunohistochemical staining for IgA–strong mesangial and focal paramesangial staining, early subendothelial deposits are also appreciated (C). Strong mesangial staining was noted in occasional glomeruli which did not exhibit mesangial hypercellularity (D).
See this image and copyright information in PMC

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