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Review
. 2022 Oct 28:16:1006836.
doi: 10.3389/fnbeh.2022.1006836. eCollection 2022.

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Clairton Marcolongo-Pereira  1 , Fernanda Cristina de Abreu Quintela Castro  1 , Rafael Mazioli Barcelos  1 , Kelly Cristina Mota Braga Chiepe  1 , Joamyr Victor Rossoni Junior  1 , Roberta Passamani Ambrosio  1 , Orlando Chiarelli-Neto  1 , Ana Paula Pesarico  2
Affiliations
Review

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Clairton Marcolongo-Pereira et al. Front Behav Neurosci. .

Abstract

Stress is an important factor in the development of several human pathologies. The response of rodents and humans to stress depends on many factors; some people and rodents develop stress-related mood disorders, such as depression and anxiety in humans, depression-like and anxiety-like behavior in mice and rats, while others report no new psychological symptoms in response to chronic or acute stress, and are considered susceptible and resilient to stress, respectively. Resilience is defined as the ability to thrive in the face of adversity and is a learned process that can help protect against occupational stressors and mental illnesses. There is growing interest in the underlying mechanisms involved in resilience and vulnerability to depression caused by stress, and some studies have demonstrated that individual variability in the way animals and humans respond to stress depends on several mechanisms, such as oxidative stress, neuronal plasticity, immunology and genetic factors, among others not discussed in this review, this review provides a general overview about this mechanism.

Keywords: anxiety; depression; resilience; stress; vulnerability.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Biological mechanisms of stress susceptibility and resilience.
See this image and copyright information in PMC

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