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Review
. 2022 Oct 28:13:948628.
doi: 10.3389/fgene.2022.948628. eCollection 2022.

Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion

Hui-Dong Liu  1   2 , Shao-Wei Wang  1   2
Affiliations
Review

Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion

Hui-Dong Liu et al. Front Genet. .

Erratum in

Abstract

Intrauterine adhesion (IUA) is one of the most common diseases of the reproductive system in women. It is often accompanied by serious clinical problems that damage reproductive function, such as menstrual disorder, infertility, or recurrent abortion. The clinical effect of routine treatment is not ideal, and the postoperative recurrence rate is still very high. Therefore, exploring the pathological mechanism of IUA and finding new strategies for the effective prevention and treatment of IUA are needed. The main pathological mechanism of IUA is endometrial fibrosis and scar formation. Noncoding RNA (ncRNA) plays an important role in the fibrosis process, which is one of the latest research advances in the pathophysiology of IUA. Moreover, the exosomal miRNAs derived from mesenchymal stem cells can be used to improve IUA. This paper reviewed the role of ncRNAs in IUA pathogenesis, summarized the core pathways of endometrial fibrosis regulated by ncRNAs, and finally introduced the potential of ncRNAs as a therapeutic target.

Keywords: exosome; intrauterine adhesion; mesenchymal stem cells; microRNA; noncoding-RNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Differential expression of ncRNAs in IUA (upward arrow indicates high expression, downward arrow indicates low expression).
FIGURE 2
FIGURE 2
Exosomal ncRNAs candidates for IUA treatment.
FIGURE 3
FIGURE 3
Three core signaling pathways of endometrial fibrosis involving ncRNAs.
See this image and copyright information in PMC

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