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Review
. 2022 Oct 28:9:1018674.
doi: 10.3389/fnut.2022.1018674. eCollection 2022.

Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome

Wenqian Li  1 , Chang Liu  1 , Qingmei Yang  1 , Ying Zhou  1 , Min Liu  1 , Hongying Shan  1   2
Affiliations
Review

Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome

Wenqian Li et al. Front Nutr. .

Abstract

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease that is characterized by oligo-ovulation or anovulation, hyperandrogenism, and polycystic ovaries observed using ultrasound with high clinical heterogeneity. At present, the etiology of PCOS is not clear but is thought to be related to genetic, metabolic, endocrine and environmental factors. Hyperandrogenism interacts with insulin resistance and overweight/obesity, forming a vicious cycle of mutual promotion and participating in the occurrence and progression of PCOS. Oxidative stress (OS) refers to the imbalance between the oxidation system and antioxidation system in the human body, which is associated with the occurrence and development of various diseases. Recent studies have shown that OS may be closely related to ovulation disorders in PCOS, and antioxidants can improve the oxidative stress state of PCOS. However, previous studies did not examine the effect of the interaction between OS and hyperandrogenism, insulin resistance or overweight/obesity on ovulation disorders in PCOS. This article reviews the interaction between OS and hyperandrogenism, insulin resistance and overweight/obesity; the effects of OS, hyperandrogenism, insulin resistance and overweight/obesity on ovulation disorders in PCOS; and the application of antioxidants in PCOS.

Keywords: antioxidants; hyperandrogenism; insulin resistance; overweight/obesity; ovulation disorder; oxidative stress; polycystic ovary syndrome.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The vicious circle between oxidative stress (OS) and Hyperandrogenemia (HA), insulin resistance (IR) leads to ovulation disorder in (polycystic ovary syndrome) PCOS.
See this image and copyright information in PMC

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