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Comment
. 2022 Nov 14;11(1):2146855.
doi: 10.1080/2162402X.2022.2146855. eCollection 2022.

Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi  1 , Guido Kroemer  2   3   4 , Federico Pietrocola  1
Affiliations
Comment

Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi et al. Oncoimmunology. .

Abstract

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

Keywords: Aging; autophagy; immune checkpoints; mitochondria.

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Conflict of interest statement

GK has been holding research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Tollys, and Vascage. GK has been consulting for Reithera. GK is on the Board of Directors of the Bristol Myers Squibb Foundation France. GK is a scientific co-founder of everImmune, Osasuna Therapeutics, Samsara Therapeutics, and Therafast Bio. GK is the inventor of patents covering therapeutic targeting of aging, cancer, cystic fibrosis, and metabolic disorders. GK’s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim. GK’s wife, Laurence Zitvogel, has held research contracts with 9 Meters Biopharma, Daiichi Sankyo, Pilege, was on the Board of Directors of Transgene, is a cofounder of everImmune, and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota.

Figures

Figure 1
Figure 1
Anticancer effects of spermidine.
See this image and copyright information in PMC

Comment on

References

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