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Case Reports
. 2022 Jun 20:10:2050313X221106110.
doi: 10.1177/2050313X221106110. eCollection 2022.

Systemic lupus erythematosus mimicking idiopathic multicentric Castleman disease: A diagnostic dilemma

Kuis Gunathilake  1 , Mim Rifath  2 , B M Munasinghe  1 , P Muhunthiny  2 , Gayana Vincent  2
Affiliations
Case Reports

Systemic lupus erythematosus mimicking idiopathic multicentric Castleman disease: A diagnostic dilemma

Kuis Gunathilake et al. SAGE Open Med Case Rep. .

Abstract

Castleman disease is a heterogeneous group of disorders of lymphoid tissue. It can often mimic other autoimmune diseases or malignancies, presenting a diagnostic dilemma to attending clinicians. Systemic lupus erythematosus and Castleman disease share many clinical and biochemical features rendering a special diagnostic challenge. Herein, we report a case of a young female who initially presented with features of idiopathic multicentric Castleman disease, subsequently developed antinuclear antibody positivity, and fulfilled the criteria for the diagnosis of systemic lupus erythematosus. Following the commencement of treatment for systemic lupus erythematosus, she had a marked response with resolution of altered clinical and biochemical profile.

Keywords: Castleman disease; Systemic lupus erythematosus; antinuclear antibody; lymph node; lymphoid hyperplasia.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Graph 1.
Graph 1.
Trends of investigation profile (red arrow depicts the methylprednisolone pulse therapy). (a) trends of inflammatory markers and (b) trends in main cell lines and urine proteinuria.
See this image and copyright information in PMC

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