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. 2022 Oct 31:83:104807.
doi: 10.1016/j.amsu.2022.104807. eCollection 2022 Nov.

Effects of low-dose aspirin and heparin on the pregnancy outcome in women with antiphospholipid syndrome

Latifa Baiazid  1 , Munawar Hraib  2
Affiliations

Effects of low-dose aspirin and heparin on the pregnancy outcome in women with antiphospholipid syndrome

Latifa Baiazid et al. Ann Med Surg (Lond). .

Abstract

Objective: The purpose of this study was to compare the use of low-dose aspirin alone versus prednisone and low-dose aspirin versus heparin and low-dose aspirin in the treatment of the antiphospholipid antibody syndrome in pregnant women.

Study design: A prospective, single-center randomized trial included 14 patients who were alternately assigned to treatment. Each patient had a history of recurrent miscarriage diagnosed with antiphospholipid syndrome. 5 accepted the treatment of aspirin alone, 5 accepted the combination treatment of aspirin + prednisone, and 4 accepted the combination therapy of aspirin + heparin. Data were compared by the One-way ANOVA test using IBM SPSS stats 19.

Results: There were no significant differences in patient outcome data, obstetric complications, and gestational age at delivery in live births between the 3 groups (P > 0.05). However, treatment with aspirin + heparin increased neonatal weight (P < 0.05).

Conclusions: Our data demonstrate the non-superiority one on each other of the three different regimens, except in terms of neonatal weight when aspirin + heparin were used. These findings raise questions about the need for therapies such as heparin and corticosteroids for women with antiphospholipid antibody syndrome, especially in resource-limited settings similar to Syria.

Keywords: Anti-β2 glycoprotein I antibody; Anticardiolipin antibody; Antiphospholipid syndrome; Heparin; Low-dose aspirin; Lupus anticoagulant antibody; Prednisone; Pregnancy morbidity; Thrombosis.

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Conflict of interest statement

The Authors declare that there is no conflict of interest.

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