Adding functions to pyridines

Affiliations

Comment

Jung Min Joo. Science. 2022.

. 2022 Nov 18;378(6621):710-711.

doi: 10.1126/science.ade5501. Epub 2022 Nov 17.

¹ Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, South Korea.

Abstract

Chemical reactions break a pyridine ring to allow its modification.

Radical and ionic meta-C-H functionalization of pyridines, quinolines, and isoquinolines.
Cao H, Cheng Q, Studer A. Cao H, et al. Science. 2022 Nov 18;378(6621):779-785. doi: 10.1126/science.ade6029. Epub 2022 Nov 17. Science. 2022. PMID: 36395213
Halogenation of the 3-position of pyridines through Zincke imine intermediates.
Boyle BT, Levy JN, de Lescure L, Paton RS, McNally A. Boyle BT, et al. Science. 2022 Nov 18;378(6621):773-779. doi: 10.1126/science.add8980. Epub 2022 Nov 17. Science. 2022. PMID: 36395214 Free PMC article.