Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Dec 15;92(12):918-919.
doi: 10.1016/j.biopsych.2022.09.027.

Depression Genetics as a Window Into Physical and Mental Health

Affiliations
Comment

Depression Genetics as a Window Into Physical and Mental Health

Karmel W Choi. Biol Psychiatry. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Relationship between genome-wide association study (GWAS) and polygenic score phenome-wide association study (PheWAS) designs

Comment on

References

    1. Firth J, Siddiqi N, Koyanagi A, Siskind D, Rosenbaum S, Galletly C, et al. (2019): The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. The Lancet Psychiatry, vol. 6. pp 675–712. - PubMed
    1. Kendall KM, Van Assche E, Andlauer TFM, Choi KW, Luykx JJ, Schulte EC, Lu Y (2021): The genetic basis of major depression. Psychological Medicine. pp 1–14. - PubMed
    1. Fang Y, Fritsche LG, Mukherjee B, Sen S, Richmond-Rakerd LS (2022): Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals. Biol Psychiatry. 10.1016/j.biopsych.2022.06.004 - DOI - PMC - PubMed
    1. Denny JC, Bastarache L, Roden DM (2016): Phenome-Wide Association Studies as a Tool to Advance Precision Medicine. Annu Rev Genomics Hum Genet 17: 353–373. - PMC - PubMed
    1. McCoy TH, Castro VM, Snapper L, Hart K, Januzzi JL, Huffman JC, Perlis RH (2017): Polygenic loading for major depression is associated with specific medical comorbidity. Transl Psychiatry 7: e1238. - PMC - PubMed

Publication types