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Review
. 2023 Feb;50(2):1931-1941.
doi: 10.1007/s11033-022-07904-1. Epub 2022 Nov 17.

Multifaceted roles of MAGOH Proteins

Rumela Mitra  1 , Ayushi Rehman  2 , Kusum Kumari Singh  3 , Bithiah Grace Jaganathan  4   5
Affiliations
Review

Multifaceted roles of MAGOH Proteins

Rumela Mitra et al. Mol Biol Rep. 2023 Feb.

Abstract

MAGOH and MAGOHB are paralog proteins that can substitute each other in the exon junction complex (EJC). The EJC is formed of core components EIF4A3, RBM8A, and MAGOH/MAGOHB. As a part of the EJC, MAGOH proteins are required for mRNA splicing, export, translation and nonsense-mediated mRNA decay (NMD). MAGOH is also essential for embryonic development and normal cellular functioning. The haploinsufficiency of MAGOH results in disorders such as microcephaly and cancer. The present review discusses the discovery of MAGOH, its paralog MAGOHB, their roles in cellular function as part of the EJC, and other cellular roles that are not directly associated with mRNA processing. We also discuss how MAGOH haploinsufficiency in cancer cells can be exploited to develop a novel targeted cancer treatment.

Keywords: EJC; MAGOH; MAGOHB; STAT3; cancer; paralog dependency.

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