The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on susceptibility to preeclampsia: A systematic review and meta-analysis

Abstract

Background: The aim of this meta-analysis is to investigate the association between Angiotensin II type 1 receptor (AT1R)-1166A/C, Angiotensin II type 2 receptor (AT2R)-1675A/G polymorphisms and susceptibility to preeclampsia (PE).

Methods: Online databases, including Web of Science, PubMed, EMBASE, CINAHL, CENTRAL, Scopus, Lilacs/SciELO, and Chinese National Knowledge Infrastructure, China Wan Fang, China Science and Technology Journal Database, were used to perform the literature search up to April 2022. The odds ratio (OR) and 95% confidence interval (CI) were used as effect size. The data was analyzed by Stata 15.0 software.

Results: According to the inclusion and exclusion criteria, a total of 22 case-control studies were identified, including 3524 cases and 6308 controls. Our meta-analysis showed that the AT1R -1166 A/C allele was significantly associated with susceptibility to PE (A vs C: OR = 0.82, 95% CI: 0.69-0.96, P = .013), and there was significant difference in recessive gene model (AA vs AC + CC: OR = 0.81, 95% CI: 0.67-0.97, P = .021). However, no association was found between AT2R-1675A/G polymorphism and susceptibility to PE.

Conclusion: our meta-analysis suggested that AT1R-1166A/C polymorphism had an association with susceptibility to PE, but AT2R-1675A/G polymorphism had no association with susceptibility to PE.

Figure 1.

Flow diagram of the selection of included studies.

Figure 2.

Forest plots of the AT1R -1166 A/C polymorphisms associated with susceptibility to preeclampsia. A: allele gene model; B: recessive model. AT1R = angiotensin II type 1 receptor.

Figure 3.

Forest plots of the AT2R-1675 A/G allele gene model associated with susceptibility to preeclampsia.

Figure 4.

Begg’s funnel plot for assessing publication bias of allele gene model in (A) AT1R -1166 A/C locus and (B) AT2R-1675 A/G locus related to susceptibility to preeclampsia. AT1R = angiotensin II type 1 receptor, AT2R = angiotensin II type 2 receptor.

Figure 5.

Sensitivity analysis of allele gene model in (A) AT1R -1166 A/C locus and (B) AT2R-1675 A/G locus related to susceptibility to preeclampsia. AT1R = angiotensin II type 1 receptor, AT2R = angiotensin II type 2 receptor.