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Review
. 2022 Nov 11;101(45):e31705.
doi: 10.1097/MD.0000000000031705.

BRCA2 gene mutation in cancer

Chunbao Xie  1 , Jiangrong Luo  2 , Yangjun He  3 , Lingxi Jiang  4   5 , Ling Zhong  5 , Yi Shi  4   5   6
Affiliations
Review

BRCA2 gene mutation in cancer

Chunbao Xie et al. Medicine (Baltimore). .

Abstract

Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Basic structure and binding protein of the BRCA2 gene. BRCA2 = breast cancer susceptibility gene 2.
See this image and copyright information in PMC

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