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. 2022 Nov;27(46):2200803.
doi: 10.2807/1560-7917.ES.2022.27.46.2200803.

Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022

Michaela Day  1 , Rachel Pitt  1 , Nisha Mody  1 , John Saunders  1 , Rupa Rai  1 , Achyuta Nori  1 , Hannah Church  1 , Sarah Mensforth  1 , Helen Corkin  1 , Jacqueline Jones  2 , Preneshni Naicker  3 , Wazirzada M Khan  1 , Rebecca Thomson Glover  1 , Kalani Mortimer  1 , Chloe Hylton  1 , Elizabeth Moss  1 , Thomas Joshua Pasvol  1 , Ania Richardson  1 , Suzy Sun  1 , Neil Woodford  1 , Hamish Mohammed  1 , Katy Sinka  1 , Helen Fifer  1
Affiliations

Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022

Michaela Day et al. Euro Surveill. 2022 Nov.

Abstract

Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae (ST8123; n = 8) were detected in the United Kingdom, compared with nine cases during the previous 6 years. Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftriaxone-resistant gonococcal infection within the UK.

Keywords: gonorrhoea; resistance.

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Conflict of interest statement

Conflict of interest: UKHSA’s Antimicrobial Resistance and Healthcare Associated Infections Reference Unit has received financial support for conference attendance, lectures, research projects, or contracted evaluations from numerous sources, including Accelerate, Achaogen, Allecra, Amplex, AstraZeneca, Basilea, Becton Dickinson Diagnostics, bioMerieux, Bio-Rad Laboratories, the BSAC, Cepheid, Check-Points, Cubist Pharmaceuticals, Department of Health, European Centre for Disease Prevention and Control, Enigma Diagnostics, Food Standards Agency, GlaxoSmithKline, Henry Stewart Talks, IHMA, Kalidex, Melinta, Merck Sharpe and Dohme, Meiji, Mobidiag, Momentum Biosciences, Nordic, Norgine, Rempex, Roche, Rokitan, Smith and Nephew, Trius, VenatoRx and Wockhardt. All authors declare no competing interests.

Figures

Figure
Figure
Phylogeny of recent United Kingdom ceftriaxone-resistant Neisseria gonorrhoeae genome sequences (n = 10) with all predicted ceftriaxone-resistant N. gonorrhoeae genome sequences (n = 52) publicly available in PathogenWatch, up to July 2022
See this image and copyright information in PMC

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