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. 2023 Jan;28(1):35-42.
doi: 10.1111/tmi.13830. Epub 2022 Dec 7.

Factors associated with verbal fluency in older adults living with HIV in West Africa: A longitudinal study

Charlotte Bernard  1 , Hélène Font  1 , Zélica Diallo  2 , Richard Ahonon  3 , Judicaël Malick Tine  4 , Franklin N'Guessan Abouo  2 , Aristophane Tanon  2 , Eugène Messou  3 , Moussa Seydi  4 , François Dabis  1 , Jean-François Dartigues  1 , Nathalie de Rekeneire  5
Affiliations

Factors associated with verbal fluency in older adults living with HIV in West Africa: A longitudinal study

Charlotte Bernard et al. Trop Med Int Health. 2023 Jan.

Abstract

Objective: Verbal fluency decline, observed both in aging and HIV infection, has been related to lower quality of life. This study aimed to evaluate the factors associated with categorical fluency in people living with HIV (PLHIV) aged ≥60 years living in West Africa.

Methods: In this longitudinal study, PLHIV aged ≥60 years, on antiretroviral therapy (ART) for ≥6 months were included in three clinics (two in Côte d'Ivoire, one in Senegal) participating in the West Africa International epidemiological Databases to Evaluate AIDS (IeDEA) collaboration. Categorical fluency was evaluated with the Isaacs Set Test at 60 s at baseline and 2 years later. Factors associated with verbal fluency baseline performance and annual rates of changes were evaluated using multivariate linear regression models.

Results: Ninety-seven PLHIV were included with 41 of them (42%) having a 2-year follow-up visit. The median age was 64 (62-67), 45.4% were female, and 89.7% had an undetectable viral load. The median annual change in categorical fluency scores was -0.9 (IQR: -2.7 to 1.8). Low baseline categorical fluency performance and its decline were associated with older age and being a female. Low educational level was associated with low baseline categorical fluency performance but not with its decline. Categorical fluency decline was also associated with marital status and hypertension.

Conclusions: Among older West African PLHIV, usual socio-demographic variables and hypertension were the main factors associated with low categorical fluency performance and/or its decline. Interventions that focus on supporting cardiometabolic health are highly recommended to prevent cognitive disorders in PLHIV.

Keywords: ART; HIV; West Africa; aging; cognition; verbal fluency.

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References

    1. Iudicello JE, Woods SP, Deutsch R, Grant I, The HIV Neurobehavioral Research Pr . Combined effects of aging and HIV infection on semantic verbal fluency: a view of the cortical hypothesis through the lens of clustering and switching. J Clin Exp Neuropsychol. 2012;34(5):476–88. - PMC - PubMed
    1. Iudicello JE, Woods SP, Parsons TD, Moran LM, Carey CL, Grant I. Verbal fluency in HIV infection: a meta‐analytic review. J Int Neuropsychol Soc. 2007;13(1):183–9. - PubMed
    1. Troyer AK, Moscovitch M, Winocur G. Clustering and switching as two components of verbal fluency: evidence from younger and older healthy adults. Neuropsychology. 1997;11(1):138–46. - PubMed
    1. Catheline G, Amieva H, Dilharreguy B, Bernard C, Duperron MG, Helmer C, et al. Semantic retrieval over time in the aging brain: structural evidence of hippocampal contribution. Hippocampus. 2015;25(9):1008–16. - PubMed
    1. Moscovitch M. Cognitive resources and dual‐task interference effects at retrieval in normal people: the role of the frontal lobes and medial temporal cortex. Neuropsychology. 1994;8(4):524–34.

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