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Review
. 2022 Dec;24(12):861-869.
doi: 10.1007/s11920-022-01391-8. Epub 2022 Nov 18.

Mechanisms of Action in Exposure Therapy

Kelly A Knowles  1 , David F Tolin  2   3
Affiliations
Review

Mechanisms of Action in Exposure Therapy

Kelly A Knowles et al. Curr Psychiatry Rep. 2022 Dec.

Abstract

Purpose of review: Exposure therapy is an effective treatment for anxiety-related disorders, but many individuals do not achieve full symptom relief, and return of fear is a common occurrence. Understanding how exposure therapy works enables further development of strategies to improve its effectiveness.

Recent findings: Recent studies have examined mechanisms of exposure-based interventions across multiple levels of analysis, from cognitive and behavioral changes that occur during treatment to the neurobiological mechanisms underlying fear extinction. Belief change and reductions in safety behaviors and avoidance mediate symptom improvements during exposure therapy, suggesting plausible cognitive and behavioral mechanisms. On the neural level, increased activation of prefrontal regions during extinction learning is a likely mechanism of exposure. Improved understanding of the biological mechanisms of exposure have led to exciting developments in clinical research, including pharmacological augmentation, though clinical translation of basic research has produced mixed results. Though still in development, such translational research is a promising future direction for exposure-based interventions.

Keywords: Exposure therapy; Fear extinction; Inhibitory learning; Mechanism.

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