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. 2022 Nov 18;17(11):e0277800.
doi: 10.1371/journal.pone.0277800. eCollection 2022.

B-cell activating factor (BAFF) and its receptors' expression in pediatric nephrotic syndrome is associated with worse prognosis

Jessica Forero-Delgadillo  1 , Vanessa Ochoa  1 , Jaime M Restrepo  1   2 , Laura Torres-Canchala  3 , Ivana Nieto-Aristizábal  3 , Ingrid Ruiz-Ordoñez  3 , Aura Sánchez  4 , María Claudia Barrera  5 , Carlos Andrés Jimenez  4 , Gabriel J Tobón  5   6
Affiliations

B-cell activating factor (BAFF) and its receptors' expression in pediatric nephrotic syndrome is associated with worse prognosis

Jessica Forero-Delgadillo et al. PLoS One. .

Abstract

Aim: Immune pathogenesis of nephrotic syndrome (NS) is not completely understood. We aimed to evaluate the expression of B-cell activating factor (BAFF) and its receptors in renal samples from pediatric NS patients and its relationship with renal function survival.

Materials and methods: We conducted an ambispective study on 33 patients with pediatric NS. Immunohistochemistry for BAFF, TACI, BCMA and BR3 was performed. Markers were evaluated on podocytes and interstitial inflammatory infiltrates (III). We performed Kaplan-Meier curves to describe renal function survival according to markers' expression.

Results: Thirty-three NS patients were included. Minimal change disease was seen in 21 (63.6%) patients, and focal segmental glomerulosclerosis in 12 (36.4%). BAFF was found in podocytes (18.2% of samples) and III (36.4% of samples), BAFF-R in one sample, TACI in 4 (podocytes and III), and BCMA in 5 samples of podocytes and 7 of III. BAFF on podocytes and III was associated with worst renal function at follow-up; those patients had 25% probability of having GFR >90 mL/min/1.73m2, versus 84.9% when absent (p = 0.0067). Patients with BAFF in III had 42.9% probability of having GFR>90 mL/min/1.73 m2, versus 94.1% when absent (p = 0.0063).

Conclusion: BAFF expression in renal biopsies could be a prognostic factor for renal function.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. BAFF and TACI expression in renal tissue: 1A) BAFF is expressed in the glomerular podocytes.
1B) BAFF expression in the interstitial inflammatory infiltrate. 1C) TACI expression in the glomerular podocytes. 1D) TACI expression in the interstitial inflammatory infiltrate.
Fig 2
Fig 2. Probability of eGFR >90mL/min/1.73m2 at 60 months follow-up according to BAFF expression in renal podocytes.
Fig 3
Fig 3. Probability of eGFR >90mL/min/1.73m2 at 60 months follow-up according to BAFF expression in renal interstitial inflammatory infiltrate.
Fig 4
Fig 4. Probability of eGFR >90mL/min/1.73m2 at 60 months follow-up according to BCMA expression in renal interstitial inflammatory infiltrate.
Fig 5
Fig 5. Probability of eGFR >90mL/min/1.73m2 at 60 months follow-up according to steroid response.
See this image and copyright information in PMC

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