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Review
. 2023 Jan 5;245(Pt 2):114920.
doi: 10.1016/j.ejmech.2022.114920. Epub 2022 Nov 13.

Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment

Fei-Fei Yang  1 , Ting Hu  1 , Jian-Quan Liu  1 , Xiao-Qian Yu  1 , Li-Ying Ma  2
Affiliations
Review

Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment

Fei-Fei Yang et al. Eur J Med Chem. .

Abstract

Bone marrow transplantation is regarded as the most effective immunotherapy for hematologic cancer, but it generally faces difficulties in matching. Aberrant expression of histone deacetylases (HDACs) is closely related to the occurrence and development of hematological cancer. Recent studies suggested that HDACs might play a critical role in initiating anti-cancer immune response or enhancing anti-cancer immunotherapy. Besides, combining HDAC inhibition and immunotherapy could prevent immunotherapy resistance in some degree and reach an extended treatment window. This review summarized the relationship between HDACs and immune and described the current understanding of HDACs in immunotherapy for hematologic cancer.

Keywords: HDACs; Hematologic cancer; Immunotherapy.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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