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Comment
. 2022 Dec 12;40(12):1457-1458.
doi: 10.1016/j.ccell.2022.10.023. Epub 2022 Nov 17.

Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors

Tanya Schild  1 , Kayvan R Keshari  2
Affiliations
Free article
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Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors

Tanya Schild et al. Cancer Cell. .
Free article

Abstract

Brain tumors are notoriously difficult to treat. Three recent Cancer Cell articles aim to uncover novel druggable targets in IDH mutant gliomas, diffuse midline gliomas, and medulloblastomas, respectively, and show that these brain tumor types shift their metabolism to become reliant on de novo pyrimidine synthesis.

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Conflict of interest statement

Declaration of interests K.R.K. is co-founder of Atish Technologies and serves on the Scientific Advisory Boards of NVision Imaging Technologies and Imaginostics. He holds patents related to imaging and leveraging cellular metabolism.

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  • Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.
    Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK. Gwynne WD, et al. Cancer Cell. 2022 Dec 12;40(12):1488-1502.e7. doi: 10.1016/j.ccell.2022.10.009. Epub 2022 Nov 10. Cancer Cell. 2022. PMID: 36368321

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