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Review
. 2023 Feb;27(1):27-45.
doi: 10.1016/j.cld.2022.08.003. Epub 2022 Aug 18.

Coronavirus Disease-2019 and Implications on the Liver

Patrick T Campbell  1 , Oren K Fix  2
Affiliations
Review

Coronavirus Disease-2019 and Implications on the Liver

Patrick T Campbell et al. Clin Liver Dis. 2023 Feb.

Abstract

The coronavirus disease-2019 (COVID-19) pandemic has had a large impact on patients with chronic liver disease (CLD) and liver transplantation (LT) recipients. Patients with advanced CLD are at a significantly increased risk of poor outcomes in the setting of severe acute respiratory syndrome coronavirus 2 infection. The pandemic has also considerably altered the management and care that is provided to patients with CLD, pre-LT patients, and LT recipients. Vaccination against COVID-19 protects patients with CLD and LT recipients from adverse outcomes and is safe in these patients; however, vaccine efficacy may be reduced in LT recipients and other immunosuppressed patients.

Keywords: Cirrhosis; Immunosuppression; SARS-CoV-2; Transplant; Vaccination.

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Conflict of interest statement

Disclosure The authors have no relevant commercial or financial conflicts of interest and no funding was received for this article.

Figures

Fig. 1
Fig. 1
Potential causes of COVID-19-related liver injury. DILI, drug-induced liver injury.
Fig. 2
Fig. 2
Algorithm for the evaluation of abnormal liver biochemistries in the patient with COVID-19. DILI, drug-induced liver injury; MRCP, magnetic resonance cholangiopancreatography; ULN, upper limit of normal.
See this image and copyright information in PMC

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