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Review
. 2023 Jan;9(1):9-27.
doi: 10.1016/j.trecan.2022.09.005. Epub 2022 Nov 16.

Challenges in glioblastoma research: focus on the tumor microenvironment

Andreas Bikfalvi  1 , Cristine Alves da Costa  2 , Tony Avril  3 , Jean-Vianney Barnier  4 , Luc Bauchet  5 , Lucie Brisson  6 , Pierre Francois Cartron  7 , Hélène Castel  8 , Eric Chevet  3 , Hervé Chneiweiss  9 , Anne Clavreul  10 , Bruno Constantin  11 , Valérie Coronas  11 , Thomas Daubon  12 , Monique Dontenwill  13 , Francois Ducray  14 , Natacha Enz-Werle  13 , Dominique Figarella-Branger  15 , Isabelle Fournier  16 , Jean-Sébastien Frenel  8 , Mathieu Gabut  14 , Thierry Galli  17 , Julie Gavard  7 , Gilles Huberfeld  18 , Jean-Philippe Hugnot  19 , Ahmed Idbaih  20 , Marie-Pierre Junier  9 , Thomas Mathivet  6 , Philippe Menei  10 , David Meyronet  21 , Céline Mirjolet  22 , Fabrice Morin  8 , Jean Mosser  3 , Elisabeth Cohen-Jonathan Moyal  23 , Véronique Rousseau  4 , Michel Salzet  16 , Marc Sanson  20 , Giorgio Seano  24 , Emeline Tabouret  25 , Aurélie Tchoghandjian  25 , Laurent Turchi  26 , Francois M Vallette  7 , Somya Vats  17 , Maité Verreault  20 , Thierry Virolle  26
Affiliations
Review

Challenges in glioblastoma research: focus on the tumor microenvironment

Andreas Bikfalvi et al. Trends Cancer. 2023 Jan.

Erratum in

  • Challenges in glioblastoma research: focus on the tumor microenvironment: (Trends in Cancer, 9:1 p:9-27, 2023).
    Bikfalvi A, da Costa CA, Avril T, Barnier JV, Bauchet L, Brisson L, Cartron PF, Castel H, Chevet E, Chneiweiss H, Clavreul A, Constantin B, Coronas V, Daubon T, Dontenwill M, Ducray F, Entz-Werlé N, Figarella-Branger D, Fournier I, Frenel JS, Gabut M, Galli T, Gavard J, Huberfeld G, Hugnot JP, Idbaih A, Junier MP, Mathivet T, Menei P, Meyronet D, Mirjolet C, Morin F, Mosser J, Moyal EC, Rousseau V, Salzet M, Sanson M, Seano G, Tabouret E, Tchoghandjian A, Turchi L, Vallette FM, Vats S, Verreault M, Virolle T. Bikfalvi A, et al. Trends Cancer. 2023 Aug;9(8):692. doi: 10.1016/j.trecan.2023.02.006. Epub 2023 Mar 28. Trends Cancer. 2023. PMID: 36997420 No abstract available.

Abstract

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has been recognized as an important player and therapeutic target in GBM. However, there is a need for a full and integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. In this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France. We propose a holistic view of the subject by delineating the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.

Keywords: glioblastoma; invasion; resistance to therapy; tumor microenvironment.

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Conflict of interest statement

Declaration of interests None declared by authors.

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