Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice
- PMID: 36400933
- PMCID: PMC9684073
- DOI: 10.1038/s42255-022-00671-0
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice
Erratum in
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Author Correction: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.Nat Metab. 2023 Jan;5(1):182. doi: 10.1038/s42255-022-00726-2. Nat Metab. 2023. PMID: 36572825 Free PMC article. No abstract available.
Retraction in
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Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.Nat Metab. 2025 Jul;7(7):1493. doi: 10.1038/s42255-025-01344-4. Nat Metab. 2025. PMID: 40604157 Free PMC article. No abstract available.
Abstract
Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-dissipating capacity but how BAT modulates vascular function and atherosclerosis through endocrine mechanisms remains poorly understood. Here we show that BAT-derived neuregulin-4 (Nrg4) ameliorates atherosclerosis in mice. BAT-specific Nrg4 deficiency accelerates vascular inflammation and adhesion responses, endothelial dysfunction and apoptosis and atherosclerosis in male mice. BAT-specific Nrg4 restoration alleviates vascular inflammation and adhesion responses, attenuates leukocyte homing and reduces endothelial injury and atherosclerosis in male mice. In endothelial cells, Nrg4 decreases apoptosis, inflammation and adhesion responses induced by oxidized low-density lipoprotein. Mechanistically, protein kinase B (Akt)-nuclear factor-κB signaling is involved in the beneficial effects of Nrg4 on the endothelium. Taken together, the results reveal Nrg4 as a potential cross-talk factor between BAT and arteries that may serve as a target for atherosclerosis.
© 2022. The Author(s).
Conflict of interest statement
The authors declare no competing interests.
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Comment in
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Batokine neuregulin 4 promotes atherosclerotic resolution.Nat Metab. 2022 Nov;4(11):1440-1441. doi: 10.1038/s42255-022-00669-8. Nat Metab. 2022. PMID: 36400934 No abstract available.
References
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- Libby, P. et al. Atherosclerosis. Nat. Rev. Dis. Prim.5, 56 (2019). - PubMed
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