Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023:2587:339-352.
doi: 10.1007/978-1-0716-2772-3_17.

MRI Evaluation of Gene Therapy in the Canine Model of Duchenne Muscular Dystrophy

Amy R Zalcman  1   2 , Chady H Hakim  3 , Jimmy C Lattimer  1 , James R Holland  1 , John R Dodam  1 , Dongsheng Duan  4   5   6   7
Affiliations

MRI Evaluation of Gene Therapy in the Canine Model of Duchenne Muscular Dystrophy

Amy R Zalcman et al. Methods Mol Biol. 2023.

Abstract

Magnetic resonance imaging (MRI) is a well-established and widely used technique to characterize and quantify skeletal and cardiac muscle changes in Duchenne muscular dystrophy (DMD). Recently, MRI has been explored to study disease progression and response to gene therapy in the canine DMD model. Using traditional sequences, delayed gadolinium enhancement, novel sequences, and spectroscopy, investigators have begun to (i) establish the baseline MRI characteristics of the muscles in normal and affected dogs and (ii) evaluate gene therapy outcomes in treated dogs. As a noninvasive assay, MRI offers an excellent opportunity to study longitudinal muscle changes in long-term gene therapy studies in the canine model. In this chapter, we outline the MRI method used to study DMD in the canine model.

Keywords: Canine model; Cardiac muscle; DMD; Duchenne muscular dystrophy; Heart; MRI; Magnetic resonance imaging; Skeletal muscle; Spectroscopy.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Dahlqvist JR, Widholm P, Leinhard OD et al (2020) MRI in neuromuscular diseases: an emerging diagnostic tool and biomarker for prognosis and efficacy. Ann Neurol 88(4):669–681. https://doi.org/10.1002/ana.25804 - DOI - PubMed
    1. Jungbluth H (2017) Myopathology in times of modern imaging. Neuropathol Appl Neurobiol 43(1):24–43. https://doi.org/10.1111/nan.12385 - DOI - PubMed
    1. Mercuri E, Pichiecchio A, Allsop J et al (2007) Muscle MRI in inherited neuromuscular disorders: past, present, and future. J Magn Reson Imaging 25(2):433–440. https://doi.org/10.1002/jmri.20804 - DOI - PubMed
    1. Aivazoglou LU, Guimaraes JB, Link TM et al (2021) MR imaging of inherited myopathies: a review and proposal of imaging algorithms. Eur Radiol. https://doi.org/10.1007/s00330-021-07931-9
    1. Duan D, Goemans N, Takeda S et al (2021) Duchenne muscular dystrophy. Nat Rev Dis Primers 7:13 - DOI - PubMed

Publication types

LinkOut - more resources