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Case Reports
. 2023 Jan;102(1):239-242.
doi: 10.1007/s00277-022-05032-1. Epub 2022 Nov 19.

Mutations in the plasma cell clone identify mechanism of polyneuropathy in a case of POEMS syndrome associated with Castleman disease and multiple myeloma

Annamaria Brioli #  1   2 , Antje Wyrwa #  1 , Ulrike Rüddel  1 , Olaposi Yomade  1 , Udo Lindig  1 , Wiebke Franz  3 , Hans-Heinrich Wacker  3 , Nikolaus Gaßler  4 , Stefan Schweyer  5 , Ha-Yeun Chung  6 , Hubertus Axer  6 , Otto W Witte  6 , Andreas Hochhaus  1 , Karin G Schrenk  7
Affiliations
Case Reports

Mutations in the plasma cell clone identify mechanism of polyneuropathy in a case of POEMS syndrome associated with Castleman disease and multiple myeloma

Annamaria Brioli et al. Ann Hematol. 2023 Jan.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Upper and middle panel: Multiple hemangiomas of the skin a, bone marrow biopsy at initial presentation revealed polyclonal plasma cells (400 × magnification) b, with progression to multiple myeloma (400 × magnification) c. Hematoxylin–eosin staining of lymph node with onion skin layers (10 × magnification) d, staining of dendritic reticulum cells (KiM4P 10 × magnification) e, and of lambda light chain (10 × magnification) f. Lower panel: Electrophysiological studies with no pathological findings on initial presentation g-h, decrease in conduction velocity and elongation of F-wave latencies after progression into multiple myeloma g-h. NR, no response. NGS-analysis of initial lymph node biopsy and bone marrow after progression into multiple myeloma demonstrating differential alteration of DTX1 in lymph node biopsy and GNAS in bone marrow biopsy on progression into multiple myeloma. EP300, JARID2, PC, PD-L2, and SETBP1 alterations were found in both biopsies. VAF, variant allele frequency i
See this image and copyright information in PMC

References

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